Evidence map›Paper›PMID 22581511›Full record

SynthesisNeurourology and urodynamics2012

Effectiveness of percutaneous posterior tibial nerve stimulation for overactive bladder: a systematic review and meta-analysis.

C Burton, A Sajja, P M Latthe

4 registry-linked trialsAbstract readEditorialMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neurourology and urodynamics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 55 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 6 pooled it
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04483817 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Efficacy of Transcutaneous Versus Percutaneous Posterior Tibial Nerve Stimulation in the Treatment of Overactive Bladder. Randomized Clinical Trial.

TypeinterventionalSponsorFisiocore LC,SLRan2019 to 2023Enrolled104ConditionsOveractive Bladder SyndromeArmsTranscutaneous tibial nerve stimulation, Percutaneous tibial nerve stimulation
NCT05309993 naterminatednot on this mapstarted 2022, after this paper: background citation

INvestigation of TENS Efficacy Versus Posterior Tibial Nerve Stimulation for Overactive Bladder

TypeinterventionalSponsorUniversity of New MexicoRan2022 to 2025Enrolled27ConditionsOveractive Bladder, Overactive Bladder Syndrome, Urinary Urge Incontinence, Urinary Bladder, OveractiveArmsPTNS, TENS
NCT06777134 recruitingnot on this mapstarted 2025, after this paper: background citation

Relationship Between Pelvic Floor Dysfunctions and Core Endurance, Hip Rotation Muscle Strength, Tibialis Anterior and Tibialis Posterior Muscle Activation in Patients With Multiple Sclerosis

TypeobservationalSponsorBerivan Beril KılıçRan2025 to 2027Enrolled73ConditionsMultiple Sclerosis, Pelvic Floor DysfunctionArmsAssessment of pelvic floor dysfunction, The Quality of Life Assessment, Core endurance assessment, Hip strength assessment, Tibialis posterior muscle activation
NCT07710794 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Transcutaneous Tibial Nerve Stimulation (TTNS) Patch Combined With Behavioral Therapy (BT) Versus Behavioral Therapy in the Treatment of Patients With Lower Urinary Tract Symptoms (LUTS) After Benign Prostatic Hyperplasia (BPH) Surgery: a Prospective, Randomized Controlled Study

TypeinterventionalSponsorQilu Hospital of Shandong UniversityRan2026 to 2027Enrolled70ConditionsLower Urinary Tract Symptoms (LUTS), BPH (Benign Prostatic Hyperplasia)ArmsTranscutaneous Tibial Nerve Stimulation (TTNS), Behavioral Treatment
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 6 syntheses or guidelines pooled it, 183 citations in OpenAlex.

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  6. Overactive bladder - 18 years - Part II.International braz j urol : official journal of the Brazilian Society of Urology
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

C BurtonDepartment of Obstetrics & Gynaecology, Birmingham Women’s NHS Foundation Trust, Birmingham, United Kingdom. cpburton@doctors.org.uk
A Sajja
P M Latthe
Birmingham Women’s and Children’s NHS Foundation Trust · GB

Funding

Department of Health 09/22/122
6 · The paper itself

Abstract

aimTo evaluate the effectiveness of posterior percutaneous tibial nerve stimulation (PTNS) in treating overactive bladder (OAB) symptoms by systematic review of the literature.

methodsSystematic literature search was carried out (up to April 2011) using relevant search terms in Medline, EMBASE, CINAHL, CENTRAL, National Library for Health, MetaRegister of controlled trials, LILACS, and Google Scholar. Relevant randomized controlled trials (RCTs) and prospective studies were selected and then analyzed by two-independent reviewers. Meta-analysis was performed with random effects model using STATA 8 for non-randomized prospective studies and with Review Manager 5.1 for RCTs.

resultsThe studies report variable initial success rates (37-82%) for treating OAB symptoms with PTNS. Four randomized trials compared PTNS with Sham treatment showing a significant difference favoring PTNS [RR 7.02 95% confidence interval (CI) 1.69-29.17]. Two randomized trials compared PTNS with antimuscarinic medication with no significant difference in the change in bladder diary parameters between the treatments. Ten prospective non-randomized studies were included. The definitions of success were varied. The pooled subjective success rate was 61.4% (95% CI 57.5-71.8) and objective success rate was 60.6% (95% CI 49.2-74.7).

conclusionThere is evidence of significant improvement in OAB symptoms using PTNS which is comparable to the effect of antimuscarinics but with a better side effect profile. The studies included in the review only considered short-term outcomes after initial treatment. In order to recommend PTNS as a practical treatment option, long-term data and health economic analysis are needed.

Indexed as

Transcutaneous Electric Nerve StimulationAdolescentAdultAgedAged, 80 and overChi-Square DistributionFemaleHumansMaleMiddle AgedMuscarinic AntagonistsOdds RatioRecovery of FunctionTibial NerveTreatment OutcomeUrinary BladderMuscarinic Antagonists

Identifiers

PMID22581511
OpenAlexW2132279199

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.