Trial reportSleep & breathing = Schlaf & Atmung2013
Treatment of obstructive sleep apnea using a custom-made titratable duobloc oral appliance: a prospective clinical study.
Trial report in Sleep & breathing = Schlaf & Atmung, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Functional imaging improves patient selection for mandibular advancement device treatment outcome in sleep-disordered breathing: a prospective study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Trial
- Mandibular Advancement Device Treatment Efficacy Is Associated with Polysomnographic Endotypes.Annals of the American Thoracic Society · 2021Trial
- A stepwise titration protocol for oral appliance therapy in positional obstructive sleep apnea patients: proof of concept.Sleep & breathing = Schlaf & Atmung · 2020Trial
- Objective measurement of compliance during oral appliance therapy for sleep-disordered breathing.Thorax · 2013Trial
- Advancing Obstructive Sleep Apnea Management: Recent Trends from Conventional to Innovative Therapies.Journal of clinical medicine · 2025Review
- Effects of mandibular advancement devices on the evolution of obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2024Article
- Drug-induced sleep endoscopy improves intervention efficacy among patients treated for obstructive sleep apnea with a mandibular advancement device.Sleep & breathing = Schlaf & Atmung · 2022Article
- Mandibular advancement device therapy in patients with epiglottic collapse.Sleep & breathing = Schlaf & Atmung · 2022Article
- Correlation between Polysomnographic Parameters and Tridimensional Changes in the Upper Airway of Obstructive Sleep Apnea Patients Treated with Mandibular Advancement Devices.Journal of clinical medicine · 2021Article
- The relationship between specific nasopharyngoscopic features and treatment deterioration with mandibular advancement devices: a prospective study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- Phenotypic Labelling Using Drug-Induced Sleep Endoscopy Improves Patient Selection for Mandibular Advancement Device Outcome: A Prospective Study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Article
- The effectiveness of two types of MADS for OSA therapy.Clinical oral investigations · 2018Observational
- Three-dimensional Evaluation of Nasal Surgery in Patients with Obstructive Sleep Apnea.Chinese medical journal · 2016Article
- Effects of mandibular advancement device treatment on arterial stiffness and glucose metabolism in patients with mild to moderate obstructive sleep apnea: a prospective 1 year study.Sleep & breathing = Schlaf & Atmung · 2016Article
- Clinical consequences and economic costs of untreated obstructive sleep apnea syndrome.World journal of otorhinolaryngology - head and neck surgery · 2015Review
- Obstructive sleep apnea and mandibular advancement splints: occlusal effects and progression of changes associated with a decade of treatment.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2014Article
- Prevalence and clinical significance of supine-dependent obstructive sleep apnea in patients using oral appliance therapy.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2014Article
- Evaluation of the impact of a clinical pathway on the organization of a multidisciplinary dental sleep clinic.Sleep & breathing = Schlaf & Atmung · 2014Article
- Impact of type D personality on adherence to oral appliance therapy for sleep-disordered breathing.Sleep & breathing = Schlaf & Atmung · 2013Article
- The influence of a mandibular advancement plate on polysomnography in different grades of obstructive sleep apnea.Journal of oral & maxillofacial researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis prospective clinical study investigates the efficacy of a specific custom-made titratable mandibular advancement device (MAD) for the treatment of obstructive sleep apnea (OSA). This MAD has attachments in the frontal teeth area that allow for progressive titration of the mandible.
methodsSixty-one adult OSA patients were included (age, 46.7 ± 9.0 years; male/female ratio, 45/16; apnea-hypopnea index (AHI), 23.2 ± 15.4 events/h sleep; body mass index, 27.9 ± 4.1 kg/m²). After an adaptation period, titration started based on a protocol of symptomatic benefit or upon reaching the physiological limits of protrusion. As a primary outcome, treatment response was defined as an objective reduction in AHI following MAD treatment of ≥50 % compared to baseline, and treatment success as a reduction in AHI with MAD to less than 5 and 10 events/h sleep. Compliance failure was defined as an inability to continue treatment.
resultsA statistically significant decrease was observed in AHI, from 23.4 ± 15.7 at baseline to 8.9 ± 8.6 events/h with MAD (p < 0.01). Treatment response was achieved in 42 out of 61 patients (68.8 %), whereas 42.6 % met criteria of AHI < 5 and 63.9 % achieved an AHI < 10 events/h sleep, respectively. Four patients (6.6 %) were considered as "compliance failures."
conclusionsThe present study has evaluated the efficacy of a specific custom-made titratable MAD in terms of sleep apnea reduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.