ArticleThe American journal of psychiatry2012
A developmental study of the neural circuitry mediating motor inhibition in bipolar disorder.
Article in The American journal of psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Neural correlates of impulsivity in bipolar disorder: A systematic review and clinical implications.Neuroscience and biobehavioral reviews · 2023Pooled it
- Developmental meta-analyses of the functional neural correlates of bipolar disorder.JAMA psychiatry · 2014Pooled it
- Towards a neurodevelopmental model of bipolar disorder: a critical review of trait- and state-related functional neuroimaging in adolescents and young adults.Molecular psychiatry · 2025Review
- Neurobehavioral maturation of motor response inhibition in adolescence - A narrative review.Neuroscience and biobehavioral reviews · 2022Review
- A preliminary study on functional activation and connectivity during frustration in youths with bipolar disorder.Bipolar disorders · 2021Article
- Structural and Functional Brain Correlates of Neuroprogression in Bipolar Disorder.Current topics in behavioral neurosciences · 2021Article
- Decreased Functional Connectivity of Vermis-Ventral Prefrontal Cortex in Bipolar Disorder.Frontiers in human neuroscience · 2021Article
- Brain manganese and the balance between essential roles and neurotoxicity.The Journal of biological chemistry · 2020Review
- Abnormal neural functions associated with motor inhibition deficits in schizophrenia and bipolar disorder.Human brain mapping · 2019Article
- Neural mechanisms of face emotion processing in youths and adults with bipolar disorder.Bipolar disorders · 2019Article
- Decreased anterior cingulate activation in a motor task in youths with bipolar disorder.Journal of child psychology and psychiatry, and allied disciplines · 2018Article
- Shared and differential cortical functional abnormalities associated with inhibitory control in patients with schizophrenia and bipolar disorder.Scientific reports · 2018Article
- Reversal-learning deficits in childhood-onset bipolar disorder across the transition from childhood to young adulthood.Journal of affective disorders · 2016Article
- Effects of acute aerobic exercise on neural correlates of attention and inhibition in adolescents with bipolar disorder.Translational psychiatry · 2016Article
- Rapid-response impulsivity: definitions, measurement issues, and clinical implications.Personality disorders · 2015Review
- Dimensions of manic symptoms in youth: psychosocial impairment and cognitive performance in the IMAGEN sample.Journal of child psychology and psychiatry, and allied disciplines · 2014Article
- Neural response during explicit and implicit face processing varies developmentally in bipolar disorder.Social cognitive and affective neuroscience · 2014Article
- Differentiating patterns of amygdala-frontal functional connectivity in schizophrenia and bipolar disorder.Schizophrenia bulletin · 2014Article
- Differential Anterior Cingulate Activity during Response Inhibition in Depressed Adolescents with Bipolar and Unipolar Major Depressive Disorder.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2014Article
- Meta-analyses of developing brain function in high-risk and emerged bipolar disorder.Frontiers in psychiatry · 2014Article
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10 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveDespite increased interest in the developmental trajectory of the pathophysiology mediating bipolar disorder, few studies have compared adults and youths with bipolar disorder. Deficits in motor inhibition are thought to play an important role in the pathophysiology of the illness across the age spectrum. The authors compared the neural circuitry mediating this process in bipolar youths relative to bipolar adults and in healthy volunteers.
methodParticipants were pediatric (N=16) and adult (N=23) patients with bipolar disorder and healthy child (N=21) and adult (N=29) volunteers. Functional MRI (fMRI) data were acquired while participants performed the stop-signal task.
resultsDuring failed inhibition, an age group-by-diagnosis interaction manifested in the anterior cingulate cortex, with bipolar youths exhibiting hypoactivation relative to both healthy youths and bipolar adults, and bipolar adults exhibiting hyperactivation relative to healthy adults. During successful inhibition, a main effect of diagnosis emerged in the right nucleus accumbens and the left ventral prefrontal cortex, with bipolar patients in both age groups showing less activation than healthy subjects.
conclusionsAnterior cingulate cortex dysfunction during failed motor inhibition was observed in both bipolar youths and adults, although the nature of this dysfunction differed between the two groups. Adults and youths with bipolar disorder exhibited similar deficits in activation of the nucleus accumbens and the ventral prefrontal cortex during successful inhibition. Therefore, while subcortical and ventral prefrontal cortex hypoactivation was present in bipolar patients across the lifespan, anterior cingulate cortex dysfunction varied developmentally, with reduced activation in youths and increased activation in adults during failed inhibition. Longitudinal fMRI studies of the developmental trajectory of the neural circuitry mediating motor inhibition in bipolar disorder are warranted.
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