ArticleParasitology research2012
Is the micro-agar larval development test reliable enough to detect ivermectin resistance?
Article in Parasitology research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Use of the Micro-Agar Larval Development Test to Differentiate Resistant and SusceptiblePathogens (Basel, Switzerland) · 2024Article
- Effect of Ivermectin on the Expression of P-Glycoprotein in Third-Stage Larvae ofAnimals : an open access journal from MDPI · 2023Article
- Comparative Evaluation of Two In Vitro Tests for Detection of Ivermectin Resistance in Haemonchus contortus of Small Ruminants in Uttar Pradesh, India.Acta parasitologica · 2021Article
- Resistance of strongylid nematodes to anthelmintic drugs and driving factors at Czech goat farms.BMC veterinary research · 2021Article
- Experimental evidence for the lack of sensitivity of in vivo faecal egg count reduction testing for the detection of early development of benzimidazole resistance.Parasitology research · 2021Article
- The first report of multidrug resistance in gastrointestinal nematodes in goat population in Poland.BMC veterinary research · 2020Article
- Use of Complementary Natural Feed for Gastrointestinal Nematodes Control in Sheep: Effectiveness and Benefits for Animals.Animals : an open access journal from MDPI · 2019Article
- Risk factors associated with occurrence of anthelmintic resistance in sheep of resource-poor farmers in Limpopo province, South Africa.Tropical animal health and production · 2019Article
- Genome-wide SNP analysis using 2b-RAD sequencing identifies the candidate genes putatively associated with resistance to ivermectin in Haemonchus contortus.Parasites & vectors · 2017Article
- Prevalence of anthelmintic resistance on Lithuanian sheep farms assessed by in vitro methods.Acta veterinaria Scandinavica · 2015Article
- Anthelmintic resistance in sheep gastrointestinal nematodes in Slovakia detected by in-vitro methods.BMC veterinary research · 2014Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To aid the diagnosis of anthelmintic resistance, a range of in vivo and in vitro techniques have been developed. Amongst in vitro techniques, the larval development test is the most widely employed. Six lambs were infected with susceptible (three) and ivermectin-resistant (three) isolates of Haemonchus contortus. The micro-agar larval development test (MALDT) was able to easily distinguish between susceptible and resistant isolates. Different proportions of resistant and susceptible eggs were subsequently incubated, i.e. development to the third larval stage occurred only in the resistant isolate. The percentage of resistant eggs ranged from 2 to 20.0 % of all eggs in the wells. In all cases, the MALDT was able to detect the presence of a minimum of 10 % of resistant worms amongst a susceptible background population. The probability was approximately 87 % of positively diagnosing a proportion of resistant worms of only 2-4 % within the population.
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