Evidence map›Paper›PMID 22581273›Full record

ReviewJournal of mammary gland biology and neoplasia2012

If you don't look, you won't see: intravital multiphoton imaging of primary and metastatic breast cancer.

Laura Bonapace, Jeffrey Wyckoff, Thomas Oertner, Jacco Van Rheenen, Tobias Junt, Mohamed Bentires-Alj

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of mammary gland biology and neoplasia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review of quantitative multiscale imaging of breast cancer.Journal of medical imaging (Bellingham, Wash.) · 2018
    Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Laura BonapaceFriedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, Basel, Switzerland.
Jeffrey Wyckoff
Thomas Oertner
Jacco Van Rheenen
Tobias Junt
Mohamed Bentires-Alj

Funding

European Research Council 243211
6 · The paper itself

Abstract

A fundamental hallmark of cancer is progression to metastasis and the growth of breast cancer metastases in lung, bone, liver and/or brain causes fatal complications. Unfortunately, the cellular and biochemical mechanisms of the metastatic process remain ill-defined. Recent application of intravital multiphoton microscopy (MP-IVM) to image fluorescently labeled cells in mouse models of cancer has allowed dynamic observation of this multi-step process at the cellular and subcellular levels. In this article, we discuss the use of MP-IVM in studies of breast cancer metastasis, as well as surgical techniques for exposing tumors prior to imaging. We also describe a versatile multiphoton microscope for imaging tumor-stroma interactions.

Indexed as

AnimalsBone Marrow NeoplasmsBreast NeoplasmsCell Line, TumorFemaleFluorescence Resonance Energy TransferGreen Fluorescent ProteinsImmunocompromised HostLymphatic MetastasisMammary Glands, AnimalMiceMice, TransgenicMicroscopy, Fluorescence, MultiphotonNeoplasm ProteinsNeoplasm TransplantationStromal Cellsenhanced green fluorescent proteinGreen Fluorescent ProteinsNeoplasm Proteins

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.