ReviewHeart failure reviews2013
Current management and future directions for the treatment of patients hospitalized for heart failure with low blood pressure.
Review in Heart failure reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Mineralocorticoid Receptor Antagonists, Blood Pressure, and Outcomes in Heart Failure With Reduced Ejection Fraction.JACC. Heart failure · 2020Trial
- Systolic blood pressure, cardiovascular outcomes and efficacy and safety of sacubitril/valsartan (LCZ696) in patients with chronic heart failure and reduced ejection fraction: results from PARADIGM-HF.European heart journal · 2017Trial
- Effect of Visit-to-Visit Variation of Heart Rate and Systolic Blood Pressure on Outcomes in Chronic Systolic Heart Failure: Results From the Systolic Heart Failure Treatment With the If Inhibitor Ivabradine Trial (SHIFT) Trial.Journal of the American Heart Association · 2016Trial
- Hypotension during hospitalization for acute heart failure is independently associated with 30-day mortality: findings from ASCEND-HF.Circulation. Heart failure · 2014Trial
- Inotrope use and outcomes among patients hospitalized for heart failure: impact of systolic blood pressure, cardiac index, and etiology.Journal of cardiac failure · 2014Trial
- Prognostic Markers of Adverse Outcomes in Acute Heart Failure: Use of Machine Learning and Network Analysis with Real Clinical Data.Journal of clinical medicine · 2025Article
- Article
- Determinants of mortality among seniors acutely readmitted for heart failure: racial disparities and clinical correlations.Journal of geriatric cardiology : JGC · 2022Article
- Systolic Blood Pressure and 1-Year Clinical Outcomes in Patients Hospitalized for Heart Failure.Frontiers in cardiovascular medicine · 2022Article
- 'Time is prognosis' in heart failure: time-to-treatment initiation as a modifiable risk factor.ESC heart failure · 2021 · on this mapReview
- Blood Pressure and Safety Events With Vericiguat in the VICTORIA Trial.Journal of the American Heart Association · 2021Article
- Timely and individualized heart failure management: need for implementation into the new guidelines.Clinical research in cardiology : official journal of the German Cardiac Society · 2021Review
- Guideline-directed medical therapy in real-world heart failure patients with low blood pressure and renal dysfunction.Clinical research in cardiology : official journal of the German Cardiac Society · 2021Article
- The Impact of Glucocorticoid Therapy on Guideline-Directed Medical Treatment Titration in Patients Hospitalized for Heart Failure with Low Blood Pressure: A Retrospective Study.International journal of general medicine · 2021Article
- Optimization of Heart Failure Treatment by Heart Rate Reduction.International journal of heart failure · 2020Review
- Article
- Target Doses of Heart Failure Medical Therapy and Blood Pressure: Insights From the CHAMP-HF Registry.JACC. Heart failure · 2019Observational
- Observational
- Elevation in systolic blood pressure during heart failure hospitalization is associated with increased short and long-term mortality.Medicine · 2017Observational
- Sympathetic Activation in Chronic Heart Failure: Potential Benefits of Interventional Therapies.Current hypertension reports · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
Abstract
Although patients hospitalized with heart failure have relatively low in-hospital mortality, the post-discharge rehospitalization and mortality rates remain high despite advances in treatment. Most patients admitted for heart failure have normal or high blood pressure, but 15-25 % have low systolic blood pressure with or without signs and/or symptoms of hypoperfusion. All pharmacological agents known to improve the prognosis of patients with heart failure also reduce blood pressure, and this limits their use in patients with heart failure and low blood pressure (HF-LBP). However, patients with HF-LBP have much higher in-hospital and post-discharge mortality. In these patients, a conceptually important therapeutic target is to improve cardiac output in order to alleviate signs of hypoperfusion. Accordingly, the majority of these patients will require an inotrope as cardiac dysfunction is the cause of their low cardiac output. However, the short-term use of currently available inotropes has been associated with further decreases in blood pressure and increases in heart rate, myocardial oxygen consumption and arrhythmias. Agents that improve cardiac contractility without this undesirable effects should be developed. To the best of our knowledge, the epidemiology, pathophysiology and therapy of patients with HF-LBP have not been addressed thoroughly. In June 2010, a workshop that included scientists and clinicians was held in Rome, Italy. The objectives of this meeting were to (1) develop a working definition for HF-LBP, (2) describe its clinical characteristics and pathophysiology, (3) review current therapies and their limitations, (4) discuss novel agents in development and (5) create a framework for the design and conduct of future clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.