ArticleThe American journal of psychiatry2012
Antidepressants may mitigate the effects of prenatal maternal anxiety on infant auditory sensory gating.
Article in The American journal of psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Systematic Review: Antipsychotic Medication in Pregnancy and Neurodevelopmental Outcomes in Children.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Pooled it
- Prenatal Primary Prevention of Mental Illness by Micronutrient Supplements in Pregnancy.The American journal of psychiatry · 2018Pooled it
- Infant sensory gating and a developmental cascade to autistic traits and anxiety.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Combination of taking neuropsychiatric medications and psychological distress in pregnant women, with behavioral problems in children at 2 years of age: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.PCN reports : psychiatry and clinical neurosciences · 2024Article
- A qualitative examination of the implementation of a perinatal collaborative care program.Primary health care research & development · 2022Article
- In utero exposure to antipsychotic medication and psychiatric outcomes in the offspring.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Auditory Sensory Gating in Children With Cochlear Implants: A P50-N100-P200 Study.Frontiers in neuroscience · 2021Article
- Maternal sleep quality during pregnancy is associated with neonatal auditory ERPs.Scientific reports · 2020Article
- Higher Gestational Choline Levels in Maternal Infection Are Protective for Infant Brain Development.The Journal of pediatrics · 2019Article
- Cortical Functional Connectivity Evident After Birth and Behavioral Inhibition at Age 2.The American journal of psychiatry · 2018Article
- Diminished Infant P50 Sensory Gating Predicts Increased 40-Month-Old Attention, Anxiety/Depression, and Externalizing Symptoms.Journal of attention disorders · 2017Article
- Depression and Anxiety During Pregnancy: Evaluating the Literature in Support of Clinical Risk-Benefit Decision-Making.Current psychiatry reports · 2016Review
- Endophenotypes in Schizophrenia for the Perinatal Period: Criteria for Validation.Schizophrenia bulletin · 2015Review
- Maternal mindfulness and anxiety during pregnancy affect infants' neural responses to sounds.Social cognitive and affective neuroscience · 2015Article
- Dietary choline supplementation to dams during pregnancy and lactation mitigates the effects of in utero stress exposure on adult anxiety-related behaviors.Behavioural brain research · 2014Article
- P50 sensory gating in infants.Journal of visualized experiments : JoVE · 2013Article
- Does fetal exposure to SSRIs or maternal depression impact infant growth?The American journal of psychiatry · 2013Article
- The last therapeutic orphan: the pregnant woman.The American journal of psychiatry · 2012Article
- Preschoolers of Mothers with Affective and Anxiety Disorders Show Impairments in Cognitive Inhibition During a Chimeric Animal Stroop.International neuropsychiatric disease journalArticle
Corrections and comments
- Commented on by
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectivePrenatal maternal anxiety has detrimental effects on the offspring's neurocognitive development, including impaired attentional function. Antidepressants are commonly used during pregnancy, yet their impact on offspring attention and their interaction with maternal anxiety has not been assessed. The authors used P50 auditory sensory gating, a putative marker of early attentional processes measurable in young infants, to assess the impact of maternal anxiety and antidepressant use.
methodA total of 242 mother-infant dyads were classified relative to maternal history of anxiety and maternal prenatal antidepressant use. Infant P50 auditory sensory gating was recorded during active sleep at a mean age of 76 days (SD=38).
resultsIn the absence of prenatal antidepressant exposure, infants whose mothers had a history of anxiety diagnoses had diminished P50 sensory gating. Prenatal antidepressant exposure mitigated the effect of anxiety. The effect of maternal anxiety was limited to amplitude of response to the second stimulus, while antidepressant exposure had an impact on the amplitude of response to both the first and second stimulus.
conclusionsMaternal anxiety disorders are associated with less inhibition during infant sensory gating, a performance deficit mitigated by prenatal antidepressant exposure. This effect may be important in considering the risks and benefits of antidepressant use during pregnancy. Cholinergic mechanisms are hypothesized for both anxiety and antidepressant effects, although the cholinergic receptors involved are likely different for anxiety and antidepressant effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.