ArticleOphthalmic plastic and reconstructive surgery
Management of radiation-induced severe anophthalmic socket contracture in patients with uveal melanoma.
Article in Ophthalmic plastic and reconstructive surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Significance of adjuvant external beam radiotherapy of the orbit in managing uveal melanoma with extraocular extension.BMJ open ophthalmology · 2026Article
- Ophthalmic complications of radiotherapy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- Twenty Years of Anophthalmic Surgery in a Tertiary Referral Center: Etiologies, Surgical Trends, and Clinical Findings.Beyoglu eye journal · 2026Article
- Ocular Complications of Radiotherapy in Uveal Melanoma.Cancers · 2023Review
- Orbital mold brachytherapy for recurrent orbital mesenchymal chondrosarcoma: a case report.Journal of contemporary brachytherapy · 2021Article
- Anophthalmic Socket Syndrome: Prevalence, Impact and Management Strategies.Clinical ophthalmology (Auckland, N.Z.) · 2021Review
- Assessing full thickness oral mucosal grafting: complications and postoperative outcomes in a broad collective of patients.BMJ open ophthalmology · 2020Article
- The reconstruction of a contracted eye socket using a post-auricular full-thickness skin graft.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2014Article
- Protein kinase C inhibitors sensitize GNAQ mutant uveal melanoma cells to ionizing radiation.Investigative ophthalmology & visual science · 2014Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
purposeHigh-dose radiotherapy can cause contracture of the anophthalmic socket, but the incidence of this complication in patients with enucleation for uveal melanoma has not been reported previously. The authors reviewed the surgical management and outcomes in terms of successful prosthesis wear in patients with severe contracture of the anophthalmic socket treated with high-dose radiotherapy for high-risk uveal melanoma, and they estimated the relative risk of this complication.
methodsThe medical records of all consecutive patients enrolled in a prospective uveal-melanoma tissue-banking protocol at the authors' institution who underwent enucleation between January 2003 and December 2010 were reviewed. Patients who underwent adjuvant radiotherapy of the enucleated socket were further studied.
resultsOf the 68 patients enrolled in the prospective tissue-banking protocol, 12 had high-risk histologic features (e.g., extrascleral spread or vortex vein invasion) and were treated with 60 Gy of external beam radiotherapy after enucleation. Five of these patients (41.7%) experienced severe socket contracture precluding prosthesis wear. The median time to onset of contracture following completion of radiotherapy was 20 months. Three patients underwent surgery, which entailed scar tissue release, oral mucous membrane grafting, and socket reconstruction; 2 patients declined surgery. All 3 patients who had surgery experienced significant improvement of socket contracture that enabled patients to wear a prosthesis again.
conclusionHigh-dose radiotherapy after enucleation in patients with uveal melanoma caused severe socket contracture and inability to wear a prosthesis in approximately 40% of patients. Surgical repair of the contracted socket using oral mucous membrane grafting can allow resumption of prosthesis wear.
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