ArticleASAIO journal (American Society for Artificial Internal Organs : 1992)
Hemodynamic design requirements for in-series thoracic artificial lung attachment in a model of pulmonary hypertension.
Article in ASAIO journal (American Society for Artificial Internal Organs : 1992). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Low-Resistance, Concentric-Gated Pediatric Artificial Lung for End-Stage Lung Failure.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2020Article
- Early in vivo experience with the pediatric continuous-flow total artificial heart.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2018Article
- Interactive simulator for e-Learning environments: a teaching software for health care professionals.Biomedical engineering online · 2014Article
- Use of a low-resistance compliant thoracic artificial lung in the pulmonary artery to pulmonary artery configuration.The Journal of thoracic and cardiovascular surgery · 2013Article
- In-parallel attachment of a low-resistance compliant thoracic artificial lung under rest and simulated exercise.The Annals of thoracic surgery · 2012Article
- Pediatric Artificial Lung: A Low-Resistance Pumpless Artificial Lung Alleviates an Acute Lamb Model of Increased Right Ventricle Afterload.ASAIO journal (American Society for Artificial Internal Organs : 1992)Article
- Darcy Permeability of Hollow Fiber Membrane Bundles Made from Membrana Polymethylpentene Fibers Used in Respiratory Assist Devices.ASAIO journal (American Society for Artificial Internal Organs : 1992)Article
- Design and in vitro assessment of an improved, low-resistance compliant thoracic artificial lung.ASAIO journal (American Society for Artificial Internal Organs : 1992)Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Recent thoracic artificial lung (TAL) prototypes have impedances lower than the natural lung. With these devices, proximal pulmonary artery (PA) to distal PA TAL attachment may be possible in patients without right ventricular dysfunction. This study examined the relationship between pulmonary system impedance and cardiac output (CO) to create TAL design constraints. A circuit with adjustable resistance and compliance (C) was attached in a PA-PA fashion with the pulmonary circulation of seven sheep with chronic pulmonary hypertension. The pulmonary system zeroth harmonic impedance modulus (Z(0)) was increased by 1, 2.5, and 4 mmHg/(L/min) above baseline. At each Z(0), C was set to 0, 0.34, and 2.1 ml/mmHg. The change in pulmonary system zeroth and first harmonic impedance moduli (ΔZ(0) and ΔZ(1)), the percent change in CO (%ΔCO), and the inlet and outlet anastomoses resistances were calculated for each situation. Results indicate that ΔZ(0) (p < 0.001) but not ΔZ(1) (p = 0.5) had a significant effect on %ΔCO and that %ΔCO = -7.45*ΔZ(0) (R(2) = 0.57). Inlet and outlet anastomoses resistances averaged 0.77 ± 0.16 and 0.10 ± 0.19 mmHg/(L/min), respectively, and the relationship between %ΔCO and TAL resistance, R(T), in mmHg/(L/min) was determined to be %ΔCO = -(7.45f)×(R(T) + 0.87), in which f = the fraction of CO through the TAL. Thus, newer TAL designs can limit %ΔCO to less than 10% if f < 0.75.
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