Trial reportSurgical endoscopy2012
Short-term outcomes of laparoscopic intersphincteric resection from a phase II trial to evaluate laparoscopic surgery for stage 0/I rectal cancer: Japan Society of Laparoscopic Colorectal Surgery Lap RC.
Trial report in Surgical endoscopy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Laparoscopic intersphincteric resection versus an open approach for low rectal cancer: a meta-analysis.World journal of surgical oncology · 2017Pooled it
- A multicentre prospective study of anal function after laparoscopic ultra-low rectal cancer surgery using a mixed-effects model.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Trial
- Short-term outcomes of laparoscopic intersphincteric resection with intraoperative radiotherapy using low-energy X-rays for primary locally advanced low rectal cancer: a single center experience.World journal of surgical oncology · 2020Trial
- My Encounters and Progress with Minimally Invasive Surgery.Juntendo medical journal · 2025Article
- Benefits and risks of diverting stoma creation during rectal cancer surgery.Annals of coloproctology · 2024Article
- Study of Purse-string Skin Closure Plus Negative-pressure Wound Therapy for Stoma Closure.Juntendo Iji zasshi = Juntendo medical journal · 2022Article
- Review
- Early and Late Functional Outcomes of Anal Sphincter-Sparing Procedures With Total Mesorectal Excision for Anorectal AdenocarcinomaAnnals of coloproctology · 2020Article
- Transanal TME: new standard or fad?Journal of the anus, rectum and colon · 2019Review
- A comparison of the long-term anorectal function between laparoscopic intersphincteric resection and low anterior resection for low rectal cancer.Surgery today · 2018Article
- Safety and feasibility of laparoscopic intersphincteric resection for a lower rectal tumor.Oncology letters · 2017Article
- Robot-assisted intersphincteric resection facilitates an efficient sphincter-saving in patients with low rectal cancer.International journal of colorectal disease · 2017Observational
- Laparoscopic assisted low anterior resection for advanced rectal cancer in a kidney transplant recipient: A case report.Medicine · 2016Article
- Evaluation of the intestinal blood flow near the rectosigmoid junction using the indocyanine green fluorescence method in a colorectal cancer surgery.International journal of colorectal disease · 2015Article
- Laparoscopic intersphincteric resection using needlescopic instruments.Journal of minimal access surgery · 2014Article
- Risk factors and predictive factors for anastomotic leakage after resection for colorectal cancer: reappraisal of the literature.Surgery today · 2014Review
- Repeated laparoscopic resection of extra-regional lymph node metastasis after laparoscopic radical resection for rectal cancer.Journal of minimal access surgeryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLaparoscopic intersphincteric resection (Lap ISR) is not yet an established technique and its safety and feasibility are unclear. Our aim was to clarify the safety and feasibility of Lap ISR for clinical stage 0/I rectal cancer (Lap RC) in a prospective multicenter study of laparoscopic surgery in Japan.
methodsTo examine the technical and oncological feasibility of laparoscopic surgery for rectal cancer, we conducted a confirmatory phase II trial to evaluate laparoscopic surgery for preoperative clinical stage 0/I rectal cancer. Eligibility criteria included histologically proven carcinoma, size ≤ 8 cm, age 20-75 years, no bowel obstruction, and no prior chemotherapy or radiotherapy. Between February 2008 and September 2010, 495 patients with rectal cancer underwent laparoscopic surgery at 43 institutions. Patients' background characteristics and operative and postoperative outcomes were recorded prospectively.
resultsSeventy-seven patients (15.6 %) underwent Lap ISR. A diverting stoma was created in 69 patients (89.6 %). Conversion to open surgery occurred in 4 patients (5.2 %): 2 patients were converted because of uncontrollable bleeding, and the other 2 patients because of the need for pelvic side wall lymphadenectomy. There was no mortality. Median operative time was 345 min (range = 198-565), median amount of blood loss was 100 ml (range = 0-1760), and three patients (3.9 %) were transfused intraoperatively. The median number of dissected lymph nodes was 14 (range = 3-33), and all (proximal, distal, and vertical) pathological cut margins were negative. Postoperative complications of grade 2 or more were detected in 17 patients (22.1 %), including anastomotic leakage in 5 (6.4 %), bowel obstruction in 5 (6.5 %), and surgical site infection in 2 (2.6 %). Abdominal drainage and diverting stoma were necessary in two patients (2.6 %) due to anastomotic leakage. Median length of postoperative hospital stay was 13 days (range = 7-167).
conclusionLap ISR was feasible and safe for clinical stage 0/I rectal cancer with favorable short-term outcome.
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Registered trials
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