ArticleClinical journal of the American Society of Nephrology : CJASN2012
Subclinical cardiac abnormalities and kidney function decline: the multi-ethnic study of atherosclerosis.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Impaired Kidney Function, Subclinical Myocardial Injury, and Their Joint Associations with Cardiovascular Mortality in the General Population.Journal of clinical medicine · 2025Article
- Cardiovascular Risk and Its Presentation in Chronic Kidney Disease.Journal of clinical medicine · 2025Review
- Prognostic Capability of Clinical SYNTAX Score in Patients with Complex Coronary Artery Disease and Chronic Renal Insufficiency Undergoing Percutaneous Coronary Intervention.Reviews in cardiovascular medicine · 2024Article
- Association of coronary artery calcification and thoracic aortic calcification with incident peripheral arterial disease in the Multi-Ethnic Study of Atherosclerosis (MESA).European heart journal open · 2021Article
- Renal dysfunction in cardiovascular diseases and its consequences.Journal of nephrology · 2021Review
- Opposing Associations of NT-proBNP With Risks of Diabetes and Diabetes-Related Complications.Diabetes care · 2020Article
- Relationship of fibroblast growth factor 21 with kidney function and albuminuria: multi-ethnic study of atherosclerosis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2019Article
- Pathophysiology and treatment of cardiovascular disease in pediatric chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2019Review
- Echocardiographic parameters and renal outcomes in patients with preserved renal function, and mild- moderate CKD.BMC nephrology · 2018Article
- Echocardiographic Measures and Estimated GFR Decline Among African Americans: The Jackson Heart Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2017Article
- Association of cardiovascular disease risk factors with left ventricular mass, biventricular function, and the presence of silent myocardial infarction on cardiac MRI in an asymptomatic population.The international journal of cardiovascular imaging · 2016Article
- Systolic blood pressure values might further risk-stratify the adverse outcomes of LVH in older patients with chronic kidney disease.Clinical hypertension · 2016Article
- Associations of kidney injury markers with subclinical cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis.Clinical nephrology · 2015Article
- Chronic Renal Insufficiency Cohort Study (CRIC): Overview and Summary of Selected Findings.Clinical journal of the American Society of Nephrology : CJASN · 2015Review
- Utility of traditional circulating and imaging-based cardiac biomarkers in patients with predialysis CKD.Clinical journal of the American Society of Nephrology : CJASN · 2015Review
- NT-proBNP and troponin T and risk of rapid kidney function decline and incident CKD in elderly adults.Clinical journal of the American Society of Nephrology : CJASN · 2015Article
- Associations of N-terminal pro-B-type natriuretic peptide with kidney function decline in persons without clinical heart failure in the Heart and Soul Study.American heart journal · 2014Article
- Low serum bicarbonate and kidney function decline: the Multi-Ethnic Study of Atherosclerosis (MESA).American journal of kidney diseases : the official journal of the National Kidney Foundation · 2014Article
- N-terminal fragment of probrain natriuretic peptide is associated with diabetes microvascular complications in type 2 diabetes.Vascular health and risk management · 2014Article
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Authors and funding
7 authors.
Funding
Abstract
BACKGROUND AND
objectivesClinical heart failure (HF) is associated with CKD and faster rates of kidney function decline. Whether subclinical abnormalities of cardiac structure are associated with faster kidney function decline is not known. The association between cardiac concentricity and kidney function decline was evaluated. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This is a longitudinal study of 3866 individuals from the Multi-Ethnic Study of Atherosclerosis (2000-2007) who were free of clinical cardiovascular disease, with an estimated GFR (eGFR) ≥60 ml/min per 1.73 m(2) at baseline and 5 years of follow-up. Concentricity, a measurement of abnormal cardiac size, was assessed by magnetic resonance imaging and evaluated as a continuous measurement and in quartiles. GFR was estimated by creatinine (eGFRcr) and cystatin C (eGFRcys). The association of concentricity with annual eGFR decline, incident CKD, and rapid kidney function decline (>5% per year) was investigated using linear mixed models as well as Poisson and logistic regression, respectively. Analyses adjusted for demographics, BP, diabetes, and inflammatory markers.
resultsMedian decline was -0.8 (interquartile range, -3.1, -0.5) by eGFRcr. Compared with the lowest quartile of concentricity, persons in the highest quartile had an additional 21% (9%-32%) decline in mean eGFRcr in fully adjusted models. Concentricity was also associated with incident CKD and with rapid kidney function decline after adjustment.
conclusionsSubclinical abnormalities in cardiac structure are associated with longitudinal kidney function decline independent of diabetes and hypertension. Future studies should examine mechanisms to explain these associations.
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