ArticleDevelopmental biology2012
The Drosophila BCL6 homolog Ken and Barbie promotes somatic stem cell self-renewal in the testis niche.
Article in Developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- B Cell Lymphoma 6 (BCL6): A Conserved Regulator of Immunity and Beyond.International journal of molecular sciences · 2024Review
- PTP61F Mediates Cell Competition and Mitigates Tumorigenesis.International journal of molecular sciences · 2021Article
- Transcriptomic analysis of the testicular fusion in Spodoptera litura.BMC genomics · 2020Article
- Varroa destructor parasitism has a greater effect on proteome changes than the deformed wing virus and activates TGF-β signaling pathways.Scientific reports · 2019Article
- Article
- Drosophila Jak/STAT Signaling: Regulation and Relevance in Human Cancer and Metastasis.International journal of molecular sciences · 2018Review
- Insulin signaling acts in adult adipocytes via GSK-3β and independently of FOXO to control Drosophila female germline stem cell numbers.Developmental biology · 2018Article
- A cell based, high throughput assay for quantitative analysis of Hedgehog pathway activation using a Smoothened activation sensor.Scientific reports · 2017Article
- Signaling pathway for phagocyte priming upon encounter with apoptotic cells.The Journal of biological chemistry · 2017Article
- Niche signaling promotes stem cell survival in the Drosophila testis via the JAK-STAT target DIAP1.Developmental biology · 2015Article
- Stem cell autotomy and niche interaction in different systems.World journal of stem cells · 2015Review
- Adipocyte amino acid sensing controls adult germline stem cell number via the amino acid response pathway and independently of Target of Rapamycin signaling in Drosophila.Development (Cambridge, England) · 2014Article
- The Jak-STAT target Chinmo prevents sex transformation of adult stem cells in the Drosophila testis niche.Developmental cell · 2014Article
- Coordinate regulation of stem cell competition by Slit-Robo and JAK-STAT signaling in the Drosophila testis.PLoS genetics · 2014Article
- Stem cells supporting other stem cells.Frontiers in genetics · 2013Review
- The miR-310/13 cluster antagonizes β-catenin function in the regulation of germ and somatic cell differentiation in the Drosophila testis.Development (Cambridge, England) · 2013Article
- Review
- Jak-STAT regulation of cyst stem cell development in the Drosophila testis.Developmental biology · 2012Article
- Recent advances in Drosophila male germline stem cell biology.Spermatogenesis · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Stem cells sustain tissue regeneration by their remarkable ability to replenish the stem cell pool and to generate differentiating progeny. Signals from local microenvironments, or niches, control stem cell behavior. In the Drosophila testis, a group of somatic support cells called the hub creates a stem cell niche by locally activating the Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway in two adjacent types of stem cells: germline stem cells (GSCs) and somatic cyst stem cells (CySCs). Here, we find that ken and barbie (ken) is autonomously required for the self-renewal of CySCs but not GSCs. Furthermore, Ken misexpression in the CySC lineage induces the cell-autonomous self-renewal of somatic cells as well as the nonautonomous self-renewal of germ cells outside the niche. Thus, Ken, like Stat92E and its targets ZFH1 (Leatherman and Dinardo, 2008) and Chinmo (Flaherty et al., 2010), is necessary and sufficient for CySC renewal. However, ken is not a JAK-STAT target in the testis, but instead acts in parallel to Stat92E to ensure CySC self-renewal. Ken represses a subset of Stat92E targets in the embryo (Arbouzova et al., 2006) suggesting that Ken maintains CySCs by repressing differentiation factors. In support of this hypothesis, we find that the global JAK-STAT inhibitor Protein tyrosine phosphatase 61F (Ptp61F) is a JAK-STAT target in the testis that is repressed by Ken. Together, our work demonstrates that Ken has an important role in the inhibition of CySC differentiation. Studies of ken may inform our understanding of its vertebrate orthologue B-Cell Lymphoma 6 (BCL6) and how misregulation of this oncogene leads to human lymphomas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.