ArticleMolecular and cellular endocrinology2012
Investigating the role of adrenal cortex in organization and differentiation of the adrenal medulla in mice.
Article in Molecular and cellular endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- NEDD4 Promotes Sertoli Cell Proliferation and Adult Leydig Cell Differentiation in the Murine Testis.Endocrinology · 2025Article
- Development and function of the fetal adrenal.Reviews in endocrine & metabolic disorders · 2023Review
- Update on Biology and Genomics of Adrenocortical Carcinomas: Rationale for Emerging Therapies.Endocrine reviews · 2022Article
- Transgenic Mouse Models to Study the Development and Maintenance of the Adrenal Cortex.International journal of molecular sciences · 2022Review
- Stem cell function and plasticity in the normal physiology of the adrenal cortex.Molecular and cellular endocrinology · 2021Review
- Targeted Disruption of Lats1 and Lats2 in Mice Impairs Adrenal Cortex Development and Alters Adrenocortical Cell Fate.Endocrinology · 2020Article
- Cholesterol signaling in single cells: lessons from STAR and sm-FISH.Journal of molecular endocrinology · 2018Review
- Targeted Disruption of YAP and TAZ Impairs the Maintenance of the Adrenal Cortex.Endocrinology · 2017Article
- PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development.Nature communications · 2016Article
- Loss of smad4 in Sertoli and Leydig cells leads to testicular dysgenesis and hemorrhagic tumor formation in mice.Biology of reproduction · 2014Article
- Conditional mutagenesis of Gata6 in SF1-positive cells causes gonadal-like differentiation in the adrenal cortex of mice.Endocrinology · 2013Article
- Fetal glucocorticoid synthesis is required for development of fetal adrenal medulla and hypothalamus feedback suppression.Endocrinology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Functions of adrenal medulla, particularly synthesis of catecholamine, are under the control of glucocorticoids produced by the cortex. To further investigate whether development/differentiation of the adrenal medulla is associated with proper organization of the adrenal cortex, we examined development of the medulla in four different mouse models with various defects in the adrenal cortex. By using the Sf1/Cre mouse line that inactivates/activates genes in Steroidogenic factor 1 (SF1)-positive cells of the fetal adrenal cortex, we produced mice that exhibit either (1) cortex hypoplasia, (2) progressive degeneration of fetal adrenal cortex, (3) cortex dysgenesis, or (4) cortex-medulla disorganization. The formation of phenylethanolamine N-methyltransferase (PNMT)-positive medulla in all models indicates that differentiation of adrenal medulla is independent of the growth of adrenal cortex. However, the misplaced/dysgenic medulla in embryos where β-catenin expression is altered, suggests that the β-catenin pathway in the adrenal cortical cells plays an indirect role in controlling proper organization of the adrenal medulla.
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