ReviewProgress in retinal and eye research2012
Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease.
Review in Progress in retinal and eye research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 394 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
394 citing papers in PubMed, 4 syntheses or guidelines pooled it, 653 citations in OpenAlex.
- Retinal imaging in pre-eclamptic pregnancy: systematic review.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026Pooled it
- Exploring the role of oxidative stress in retinal vein occlusion: an updated and comprehensive review on the pathophysiology and treatment perspectives.International ophthalmology · 2025Pooled it
- Retinal and choroidal microvascular features during pregnancy: a systematic review and meta-analysis.BMJ open · 2024Pooled it
- Optical coherence tomography angiography analysis methods: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Retinal Neurovascular and Mitochondrial Function Signatures in Response to a 24-Week Yoga Intervention in Healthy Adults.Investigative ophthalmology & visual science · 2025Trial
- Clinical science effects of different mydriatics on retinal and choroidal parameters in healthy adults observed by widefield swept-source optical coherence tomography.BMJ open ophthalmology · 2025Trial
- Short-term effects of sunlight exposure on fundus blood flow perfusion in children: a randomised controlled trial.The British journal of ophthalmology · 2024Trial
- Benefits of dark chocolate intake on retinal vessels functionality: a randomized, blind, crossover clinical trial.Scientific reports · 2024Trial
- The effect of optic neuritis attacks on choroidal vascularity index in patients with multiple sclerosis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Trial
- Beyond hyperglycaemia: diabetic retinopathy is a multifactorial complication of diabetes mellitus.Annals of medicine · 2026Review
- Optical coherence tomography angiography of the macular retina and choroid in glaucoma: a narrative review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- Subclinical neurovascular and immune correlates of post-COVID-19 syndrome detected by retinal imaging.Brain, behavior, & immunity - health · 2026Article
- Review
- A clear view at altitude: layer-specific control of the choroidal circulation.Function (Oxford, England) · 2026Article
- Development and validation of an artificial intelligence-based tool to detect subclinical atheroesclerosis using non-mydriatic retinal funduscopic images: the Aitheroscope project.European heart journal. Digital health · 2026Article
- Visual Impairment Following Periocular Triamcinolone Acetonide Injection into the Lacrimal Gland: A Case Report and Literature Review.Aesthetic plastic surgery · 2026Review
- Retinal Structural and Microvascular Findings on OCT and OCTA in Hemodialysis and Kidney Transplant Recipients and Their Association with Mineral Metabolism Parameters.Medical sciences (Basel, Switzerland) · 2026Article
- Detection of Retinal Neurovascular Coupling During Light Adaptation Using Optical Coherence Tomography Angiography: A Pilot Study.Life (Basel, Switzerland) · 2026Article
- Retinal and Choroidal Microvascular Alterations Associated with Compensatory Head Tilt in Congenital Superior Oblique Palsy: An Interocular OCTA Analysis.Journal of clinical medicine · 2026Article
- Age-Dependent Retinal Parameter Correlation Patterns on OCT and OCT Angiography in Children and Adults.Journal of clinical medicine · 2026Article
334 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
We review the cellular and physiological mechanisms responsible for the regulation of blood flow in the retina and choroid in health and disease. Due to the intrinsic light sensitivity of the retina and the direct visual accessibility of fundus blood vessels, the eye offers unique opportunities for the non-invasive investigation of mechanisms of blood flow regulation. The ability of the retinal vasculature to regulate its blood flow is contrasted with the far more restricted ability of the choroidal circulation to regulate its blood flow by virtue of the absence of glial cells, the markedly reduced pericyte ensheathment of the choroidal vasculature, and the lack of intermediate filaments in choroidal pericytes. We review the cellular and molecular components of the neurovascular unit in the retina and choroid, techniques for monitoring retinal and choroidal blood flow, responses of the retinal and choroidal circulation to light stimulation, the role of capillaries, astrocytes and pericytes in regulating blood flow, putative signaling mechanisms mediating neurovascular coupling in the retina, and changes that occur in the retinal and choroidal circulation during diabetic retinopathy, age-related macular degeneration, glaucoma, and Alzheimer's disease. We close by discussing issues that remain to be explored.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.