ArticleJournal of insect physiology2012
Transcript profiling reveals mechanisms for lipid conservation during diapause in the mosquito, Aedes albopictus.
Article in Journal of insect physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 143 citations in OpenAlex.
- The evolution of reproduction without blood feeding in an invasive vector mosquito Aedes albopictus.BMC biology · 2026Article
- Review
- Photoperiod-induced Egg Shape Variation in Aedes Aegypti: a Geometric Morphometric Analysis of Laboratory and Field Samples.Neotropical entomology · 2026Article
- Suppression of transgenerational lipid provisioning inhibits desiccation resistance, but not diapause, in the vector mosquito, Aedes albopictus.Scientific reports · 2026Article
- Suppression of transgenerational lipid provisioning inhibits desiccation resistance, but not diapause, in the vector mosquito, Aedes albopictus.Research square · 2026Article
- Lipid Metabolism in Insect Vectors of Diseases.Advances in experimental medicine and biology · 2026Review
- Lipid Metabolism in Diapause.Advances in experimental medicine and biology · 2026Review
- Insect Lipids: Structure, Classification and Function.Advances in experimental medicine and biology · 2026Review
- Lipid Properties and Metabolism in Response to Cold.Advances in experimental medicine and biology · 2026Review
- Phenotypic changes in natural populations of Anopheles gambiae s.l. at the onset of the long dry season in tropical savannahs of Burkina Faso, West Africa.Parasite (Paris, France) · 2026Article
- Insights on the sex determination, vector capacity and ecological biology from a chromosomal level genome of vector mosquito, Armigeres subulbatus.Infectious diseases of poverty · 2025Article
- Prolonged exposure to heat enhances mosquito tolerance to viral infection.Communications biology · 2025Article
- Suppression of the H3K27me3 demethylase disrupts diapause formation in mosquito Culex pipiens.Insect biochemistry and molecular biology · 2025Article
- Molecular mechanisms and comparative transcriptomics of diapause in two corn rootworm species (Current research in insect science · 2025Article
- Carry-over effects of Bacillus thuringiensis on tolerant Aedes albopictus mosquitoes.Parasites & vectors · 2024Article
- Temperature and photoperiod differentially impact maternal phenotypes in diapause egg-laying Aedes albopictus mosquitoes.PLoS neglected tropical diseases · 2024Article
- Repurposing Insecticides for Mosquito Control: Evaluating Spiromesifen, a Lipid Synthesis Inhibitor againstTropical medicine and infectious disease · 2024Article
- Light pollution disrupts circadian clock gene expression in two mosquito vectors during their overwintering dormancy.Scientific reports · 2024Article
- Consuming royal jelly alters several phenotypes associated with overwintering dormancy in mosquitoes.Frontiers in insect science · 2024Article
- Eggs of the mosquito Aedes aegypti survive desiccation by rewiring their polyamine and lipid metabolism.PLoS biology · 2023Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The Asian tiger mosquito, Aedes albopictus, is a medically important invasive species whose geographic distribution has expanded dramatically during the past 20 years, and one of the key elements of its success is its capacity to survive long distance transport as a diapausing pharate first instar larva, encased within the chorion of the egg. We report that pharate larvae entering diapause are larger and contain 30% more lipid than their nondiapausing counterparts. To improve our understanding of the molecular regulation of lipid metabolism during diapause, we assessed the relative mRNA abundance of 21 genes using qRT-PCR. Elevated expression of lipid storage droplet protein 2 during embryonic development likely contributes to the higher amounts of lipid we noted in diapausing individuals. The conservation of lipids during diapause is reflected in downregulation of genes involved in lipid catabolism, including lipase 2, lipase 3, lipase 4, acyl-CoA dehydrogenase 4, and isovaleryl-CoA dehydrogenase. Two genes involved in fatty acid synthesis and modification, Δ(9)-desaturase, and fatty acyl-CoA elongase, were both upregulated in diapausing pharate larvae, suggesting roles for their gene products in generating unsaturated fatty acids to enhance membrane fluidity at low temperatures and generating precursors to the surface hydrocarbons needed to resist desiccation, respectively. Together, the results point to substantial distinctions in lipid metabolism within the embryo as a consequence of the diapause program, and these differences occur both before the actual onset of diapause as well as during the diapause state.
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