ArticleCell2012
Network medicine strikes a blow against breast cancer.
Article in Cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 58 citations in OpenAlex.
- Applying Next-Generation Sequencing and Multi-Omics in Chronic Obstructive Pulmonary Disease.International journal of molecular sciences · 2023Review
- A systems pharmacology approach based on oncogenic signalling pathways to determine the mechanisms of action of natural products in breast cancer from transcriptome data.BMC complementary medicine and therapies · 2021Article
- Revealing nuclear receptor hub modules from Basal-like breast cancer expression networks.PloS one · 2021Article
- A Near-Optimal Control Method for Stochastic Boolean Networks.Letters in biomathematics · 2020Article
- Associating expression and genomic data using co-occurrence measures.Biology direct · 2019Article
- Functional genomics screen with pooled shRNA library and gene expression profiling with extracts ofPeerJ · 2019Article
- Article
- Mechanistic and topological explanations in medicine: the case of medical genetics and network medicine.Synthese · 2018Article
- iCAVE: an open source tool for visualizing biomolecular networks in 3D, stereoscopic 3D and immersive 3D.GigaScience · 2017Article
- Article
- Comparative analysis of protein interactome networks prioritizes candidate genes with cancer signatures.Oncotarget · 2016Article
- Identification of control targets in Boolean molecular network models via computational algebra.BMC systems biology · 2016Article
- Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection.Journal of Korean medical science · 2016Article
- Pharmacogenomics in diabetes mellitus: insights into drug action and drug discovery.Nature reviews. Endocrinology · 2016Review
- Molecular network control through boolean canalization.EURASIP journal on bioinformatics & systems biology · 2015Article
- New approaches to treating Alzheimer's disease.Perspectives in medicinal chemistry · 2015Article
- SANTA: quantifying the functional content of molecular networks.PLoS computational biology · 2014Article
- Systems genetics approaches to understand complex traits.Nature reviews. Genetics · 2014Review
- Protein engineering: a new frontier for biological therapeutics.Current drug metabolism · 2014Review
- Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review.Pharmacology & therapeutics · 2013Review
Corrections and comments
- Comment on
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug development for complex diseases is shifting from targeting individual proteins or genes to systems-based attacks targeting dynamic network states. Lee et al. now reveal how the progressive rewiring of a signaling network over time following EGF receptor inhibition leaves triple-negative breast tumors vulnerable to a second, later hit with DNA-damaging drugs, demonstrating that time- and order-dependent drug combinations can be more efficacious in killing cancer cells.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.