SynthesisThe Journal of clinical psychiatry2012
D-cycloserine augmentation of behavioral therapy for the treatment of anxiety disorders: a meta-analysis.
Synthesis in The Journal of clinical psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 8 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- A comprehensive review for machine learning on neuroimaging in obsessive-compulsive disorder.Frontiers in human neuroscience · 2023Pooled it
- Changes in Dosing and Dose Timing of D-Cycloserine Explain Its Apparent Declining Efficacy for Augmenting Exposure Therapy for Anxiety-related Disorders: An Individual Participant-data Meta-analysis.Journal of anxiety disorders · 2019Pooled it
- A Meta-Analysis of D-Cycloserine in Exposure-Based Treatment: Moderators of Treatment Efficacy, Response, and Diagnostic Remission.The Journal of clinical psychiatry · 2017Pooled it
- D-cycloserine augmentation of behavior therapy for anxiety and obsessive-compulsive disorders: A meta-analysis.PloS one · 2017Pooled it
- D-Cycloserine in Neuropsychiatric Diseases: A Systematic Review.The international journal of neuropsychopharmacology · 2016Pooled it
- Augmentation of cognitive and behavioural therapies (CBT) with d-cycloserine for anxiety and related disorders.The Cochrane database of systematic reviews · 2015Pooled it
- D-cycloserine augmentation in behavioral therapy for obsessive-compulsive disorder: a meta-analysis.Drug design, development and therapy · 2015Pooled it
- Does D-cycloserine enhance exposure therapy for anxiety disorders in humans? A meta-analysis.PloS one · 2014Pooled it
- The NMDA receptor partial agonist d-cycloserine does not enhance motor learning.Journal of psychopharmacology (Oxford, England) · 2016Trial
- Enhancing panic and smoking reduction treatment with d-cycloserine: Study protocol for a randomized controlled trial.Contemporary clinical trials · 2016Trial
- D-cycloserine augmentation of cognitive behavioral group therapy of social anxiety disorder: prognostic and prescriptive variables.Journal of consulting and clinical psychology · 2013Trial
- Psychopharmacological Treatment of Obsessive-Compulsive Disorder (OCD).Current neuropharmacology · 2019Review
- Extinction learning in childhood anxiety disorders, obsessive compulsive disorder and post-traumatic stress disorder: implications for treatment.Expert review of neurotherapeutics · 2016Review
- Enhancement of Psychosocial Treatment With D-Cycloserine: Models, Moderators, and Future Directions.Biological psychiatry · 2016Review
- The effect of D-cycloserine on social anxiety treatment using a behavioral outcome measure and a post-session administration strategy.Behavior analysis (Washington, D.C.) · 2016Article
- Sleep and REM sleep disturbance in the pathophysiology of PTSD: the role of extinction memory.Biology of mood & anxiety disorders · 2015Article
- Multistage drug effects of ketamine in the treatment of major depression.European archives of psychiatry and clinical neuroscience · 2014Review
- Enhancing exposure therapy for anxiety disorders, obsessive-compulsive disorder and post-traumatic stress disorder.Expert review of neurotherapeutics · 2014Review
- From the neurobiology of extinction to improved clinical treatments.Depression and anxiety · 2014Review
- A randomized controlled trial of cognitive remediation and d-cycloserine for individuals with bipolar disorder.BMC psychology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine the efficacy of D-cycloserine augmentation of behavioral therapy for the treatment of anxiety disorders. DATA SOURCES AND STUDY SELECTION: Using the search terms D-cycloserine AND anxiety disorders (MeSH), PubMed (1965-June 2011), PsycINFO, and Scopus were searched for randomized, double-blind, placebo-controlled trials of D-cycloserine augmentation of behavioral therapy for the treatment of anxiety disorders. Anxiety disorders were defined as any disorder categorized as such in DSM-IV-TR. DATA EXTRACTION: A random-effects model was used to calculate the standardized mean difference of change in anxiety rating scale scores with D-cycloserine augmentation compared to placebo, which was the primary outcome measure. Subgroup analysis and meta-regression were used to examine the effects of D-cycloserine dosage and timing (relative to exposure therapy), diagnostic indication, number of therapy sessions, and trial methodological quality on D-cycloserine efficacy.
resultsMeta-analysis of 9 trials involving 273 subjects demonstrated a significant benefit from D-cycloserine augmentation (standardized mean difference = 0.46 [95% CI, 0.15 to 0.77], z = 2.89, P = .004). There was no evidence of publication bias, but a moderate, nonsignificant degree of heterogeneity between trials (I2 = 36%, Q = 12.6, df = 8, P = .12) was found. Secondary analyses yielded no significant findings.
conclusionsD-Cycloserine appears to be an effective augmentation agent that enhances the effects of behavioral therapy in the treatment of anxiety disorders. In contrast to a previous meta-analysis that examined D-cycloserine's effects in both animals and humans, we found no evidence of an effect of dose number, dose timing, or dosage of D-cycloserine on reported efficacy in the ranges studied.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.