ArticleThe Journal of pediatrics2012
Natural history of pediatric intestinal failure: initial report from the Pediatric Intestinal Failure Consortium.
Article in The Journal of pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 166 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Measurement of Body Composition by Air Displacement Plethysmography in Pediatric Intestinal Failure Patients
Tolerability of an Amino Acid-based Oral Rehydration Solution in Children With Short Bowel Syndrome
Oral Care: An Important Adjunctive Therapy to Improve Feeding Tolerance in Infants With Gastroschisis
Compassionate-Use of 4% T-EDTA Lock Solution for Central Venous Lines of Pediatric PN Patients
Who cites it
166 citing papers in PubMed, 4 syntheses or guidelines pooled it, 454 citations in OpenAlex.
- Clinical outcomes in pediatric intestinal failure: a meta-analysis and meta-regression.The American journal of clinical nutrition · 2019Pooled it
- Improved enteral tolerance following step procedure: systematic literature review and meta-analysis.Pediatric surgery international · 2016Pooled it
- Fish oil- and soy oil-based lipid emulsions in neonatal parenteral nutrition: a systematic review and meta-analysis.European journal of clinical nutrition · 2016Pooled it
- Working group reports: evaluation of the evidence to support practice guidelines for nutritional care of preterm infants-the Pre-B Project.The American journal of clinical nutrition · 2016Pooled it
- Postoperative Enteral Nutrition Guidelines Reduce the Risk of Intestinal Failure-Associated Liver Disease in Surgical Infants.The Journal of pediatrics · 2018Trial
- Low-Dose Parenteral Soybean Oil for the Prevention of Parenteral Nutrition-Associated Liver Disease in Neonates With Gastrointestinal Disorders.JPEN. Journal of parenteral and enteral nutrition · 2017Trial
- Pediatric intestinal failure-associated liver disease is reversed with 6 months of intravenous fish oil.JPEN. Journal of parenteral and enteral nutrition · 2014Trial
- Teduglutide in pediatric patients under 10 kg with short bowel syndrome on parenteral support: An open-label study.Pediatrics international : official journal of the Japan Pediatric SocietyTrial
- Assessment of liver fibrosis in children with intestinal failure and prolonged parenteral nutrition.Pediatric surgery international · 2026Article
- Current state of neonatal intestinal rehabilitation care in North America: A descriptive survey-based study.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026Article
- Biopsy-Proven Intestinal Failure-Associated Liver Disease in Pediatric Short Bowel Syndrome: Histopathological Findings and Clinical Outcomes.Diagnostics (Basel, Switzerland) · 2026Article
- Assessing the health-related quality of life and clinical effect in children with short bowel syndrome receiving teduglutide treatment.BMC pediatrics · 2026Article
- Serial Transverse Enteroplasty and the Reestablishment of Enteral Autonomy Among the Adult Population: New Insights With Advanced Clinical Practice and Novel Outcome Predictive Model.Annals of surgery · 2026Article
- Liver X receptor agonists enhance intestinal repair in neonatal piglets with massive bowel resection.Journal of lipid research · 2026Article
- Functional Imaging for Regenerative Medicine: Tracking Vascularization of Intestinal Scaffolds.Tissue engineering. Part A · 2026Article
- Sepsis as a confounding factor in assessing liver dysfunction in parenterally fed piglets: a model for human infants with intestinal failure.Laboratory animal research · 2026Article
- [Use of teduglutide in short bowel syndrome in infants, children and adolescents: Position paper of the working group "Chronic intestinal failure" of the Society for Paediatric Gastroenterology and Nutrition (GPGE)].Zeitschrift fur Gastroenterologie · 2026Article
- Single-center experience with pediatric short bowel syndrome: clinical outcomes based on etiology and anatomical type in a retrospective cohort study.Annals of surgical treatment and research · 2026Article
- An exploratory in vitro co-culture of enteric neurons and smooth muscle cells demonstrates neuronal contribution to muscle layer formation.Scientific reports · 2026Article
- Time to Administration, Outcome and Cost Comparison of 2 Different Strategies to Dispense Alteplase in Pediatric Intestinal Failure.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026Article
106 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 16 institutions in 2 countries.
Funding
Abstract
objectiveTo characterize the natural history of intestinal failure (IF) among 14 pediatric centers during the intestinal transplantation era. STUDY
designThe Pediatric Intestinal Failure Consortium performed a retrospective analysis of clinical and outcome data for a multicenter cohort of infants with IF. Entry criteria included infants <12 months receiving parenteral nutrition (PN) for >60 continuous days. Enteral autonomy was defined as discontinuation of PN for >3 consecutive months. Values are presented as median (25th, 75th percentiles) or as number (%).
results272 infants with a gestational age of 34 weeks (30, 36) and birth weight of 2.1 kg (1.2, 2.7) were followed for 25.7 months (11.2, 40.9). Residual small bowel length in 144 patients was 41 cm (25.0, 65.5). Diagnoses were necrotizing enterocolitis (71, 26%), gastroschisis (44, 16%), atresia (27, 10%), volvulus (24, 9%), combinations of these diagnoses (46, 17%), aganglionosis (11, 4%), and other single or multiple diagnoses (48, 18%). Prescribed medications included oral antibiotics (207, 76%), H2 blockers (187, 69%), and proton pump inhibitors (156, 57%). Enteral feeding approaches varied among centers; 19% of the cohort received human milk. The cohort experienced 8.9 new catheter-related blood stream infections per 1000 catheter days. The cumulative incidences for enteral autonomy, death, and intestinal transplantation were 47%, 27%, and 26%, respectively. Enteral autonomy continued into the fifth year after study entry.
conclusionsChildren with IF endure significant mortality and morbidity. Enteral autonomy may require years to achieve. Improved medical, nutritional, and surgical management may reduce time on PN, mortality, and need for transplantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.