ArticleJournal of autoimmunity2012
Definition of IFN-γ-related pathways critical for chemically-induced systemic autoimmunity.
Article in Journal of autoimmunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Regulatory T Cells and IFNγ in Mercury-Induced Autoimmunity: Insights from Adoptive Transfer in B10.S Mice.Biology · 2026Article
- Effect of Age on Xenobiotic-Induced Autoimmunity.bioRxiv : the preprint server for biology · 2025Article
- Identification of Key Biomarkers Associated with Immunogenic Cell Death and Their Regulatory Mechanisms in Severe Acute Pancreatitis Based on WGCNA and Machine Learning.International journal of molecular sciences · 2023Article
- Mercury-induced inflammation and autoimmunity.Biochimica et biophysica acta. General subjects · 2019Review
- Theoretical Studies on the Engagement of Interleukin 18 in the Immuno-Inflammatory Processes Underlying Atherosclerosis.International journal of molecular sciences · 2018Article
- Environmental Xenobiotic Exposure and Autoimmunity.Current opinion in toxicology · 2018Article
- C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease.Nature communications · 2018Article
- Global transcriptomic analysis suggests carbon dioxide as an environmental stressor in spaceflight: A systems biology GeneLab case study.Scientific reports · 2018Article
- Silicosis and Silica-Induced Autoimmunity in the Diversity Outbred Mouse.Frontiers in immunology · 2018Article
- Induction of Systemic Autoimmunity by a Xenobiotic Requires Endosomal TLR Trafficking and Signaling from the Late Endosome and Endolysosome but Not Type I IFN.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- From the Cover: Interplay Between IFN-γ and IL-6 Impacts the Inflammatory Response and Expression of Interferon-Regulated Genes in Environmental-Induced Autoimmunity.Toxicological sciences : an official journal of the Society of Toxicology · 2017Article
- Silica, Silicosis, and Autoimmunity.Frontiers in immunology · 2016Review
- Interferon regulatory factor 1 marks activated genes and can induce target gene expression in systemic lupus erythematosus.Arthritis & rheumatology (Hoboken, N.J.) · 2015Article
- The effect of the autoimmunity-associated gene, PTPN22, on a BXSB-derived model of lupus.Clinical immunology (Orlando, Fla.) · 2015Article
- Cathepsin B regulates the appearance and severity of mercury-induced inflammation and autoimmunity.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- A tandem repeat in decay accelerating factor 1 is associated with severity of murine mercury-induced autoimmunity.Autoimmune diseases · 2014Article
- The role of decay accelerating factor in environmentally induced and idiopathic systemic autoimmune disease.Autoimmune diseases · 2014Review
- Autoimmunity in 2012.Clinical reviews in allergy & immunology · 2013Review
- Interferon-γ and systemic autoimmunity.Discovery medicine · 2013Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
IFN-γ is essential for idiopathic and murine mercury-induced systemic autoimmunity (mHgIA), and heterozygous IFN-γ(+/-) mice also exhibit reduced disease. This suggests that blocking specific IFN-γ-related pathways that may only partially inhibit IFN-γ production or function will also suppress autoimmunity. To test this hypothesis, mice deficient in genes regulating IFN-γ expression (Casp1, Nlrp3, Il12a, Il12b, Stat4) or function (Ifngr1, Irf1) were examined for mHgIA susceptibility. Absence of either Ifngr1 or Irf1 resulted in a striking reduction of disease, while deficiency of genes promoting IFN-γ expression had modest to no effect. Furthermore, both Irf1- and Ifng-deficiency only modestly reduced the expansion of CD44(hi) and CD44(hi)CD55(lo) CD4(+) T cells, indicating that they are not absolutely required for T cell activation. Thus, there is substantial redundancy in genes that regulate IFN-γ expression in contrast to those that mediate later signaling events. These findings have implications for the therapeutic targeting of IFN-γ pathways in systemic autoimmunity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.