ArticleJournal of the American Chemical Society2012
Addition of dioxygen to an N4S(thiolate) iron(II) cysteine dioxygenase model gives a structurally characterized sulfinato-iron(II) complex.
Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 78 citations in OpenAlex.
- A Dinuclear Iron(II) Persulfide Complex Reacts with OJournal of the American Chemical Society · 2026Article
- Promiscuity in Molecular Mimics of the Cysteine Dioxygenase: Effects of Selenium in the Substrate and Cobalt as the Central Metal Ion.Angewandte Chemie (International ed. in English) · 2025Article
- Electronic Modification of a Reduced Mononuclear Nonheme Iron Nitrosyl Complex Leads to HNO Release.Journal of the American Chemical Society · 2025Article
- Influence of the second coordination sphere on OJournal of inorganic biochemistry · 2025Article
- Spectroscopic, electrochemical, and kinetic trends in Fe(III)-thiolate disproportionation near physiologic pH.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2024Article
- A Nonheme Iron(III) Superoxide Complex Leads to Sulfur Oxygenation.Journal of the American Chemical Society · 2024Article
- Electronic structures and spectroscopic signatures of diiron intermediates generated by ODalton transactions (Cambridge, England : 2003) · 2021Article
- Superoxide Oxidation by a Thiolate-Ligated Iron Complex and Anion Inhibition.Inorganic chemistry · 2021Article
- Proton-Coupled Electron-Transfer Reactivity Controls Iron versus Sulfur Oxidation in Nonheme Iron-Thiolate Complexes.Inorganic chemistry · 2021Article
- Enhancing Tris(pyrazolyl)borate-Based Models of Cysteine/Cysteamine Dioxygenases through Steric Effects: Increased Reactivities, Full Product Characterization and Hints to Initial Superoxide Formation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Spectroscopic and Computational Comparisons of Thiolate-Ligated Ferric Nonheme Complexes to Cysteine Dioxygenase: Second-Sphere Effects on Substrate (Analogue) Positioning.Inorganic chemistry · 2019Article
- Activation of Dioxygen by a Mononuclear Nonheme Iron Complex: Sequential Peroxo, Oxo, and Hydroxo Intermediates.Journal of the American Chemical Society · 2019Article
- Dioxygen-Derived Nonheme Mononuclear FeJournal of the American Chemical Society · 2019Article
- A Mononuclear, Nonheme FeJournal of the American Chemical Society · 2019Article
- A Nonheme Thiolate-Ligated Cobalt Superoxo Complex: Synthesis and Spectroscopic Characterization, Computational Studies, and Hydrogen Atom Abstraction Reactivity.Journal of the American Chemical Society · 2019Article
- Structures, Spectroscopic Properties, and Dioxygen Reactivity of 5- and 6-Coordinate Nonheme Iron(II) Complexes: A Combined Enzyme/Model Study of Thiol Dioxygenases.Journal of the American Chemical Society · 2018Article
- Observation of Radical Rebound in a Mononuclear Nonheme Iron Model Complex.Journal of the American Chemical Society · 2018Article
- A Nonheme, High-Spin {FeNO}Journal of the American Chemical Society · 2017Article
- Metal-Assisted Oxo Atom Addition to an Fe(III) Thiolate.Journal of the American Chemical Society · 2017Article
- Synthesis, X-ray Structures, Electronic Properties, and OInorganic chemistry · 2016Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
The non-heme iron enzyme cysteine dioxygenase (CDO) catalyzes the S-oxygenation of cysteine by O(2) to give cysteine sulfinic acid. The synthesis of a new structural and functional model of the cysteine-bound CDO active site, [Fe(II)(N3PyS)(CH(3)CN)]BF(4) (1) is reported. This complex was prepared with a new facially chelating 4N/1S(thiolate) pentadentate ligand. The reaction of 1 with O(2) resulted in oxygenation of the thiolate donor to afford the doubly oxygenated sulfinate product [Fe(II)(N3PySO(2))(NCS)] (2), which was crystallographically characterized. The thiolate donor provided by the new N3PyS ligand has a dramatic influence on the redox potential and O(2) reactivity of this Fe(II) model complex.
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