ArticleAddiction (Abingdon, England)2012
Mediational relations between 12-Step attendance, depression and substance use in patients with comorbid substance dependence and major depression.
Article in Addiction (Abingdon, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00018655 (Integrated Intervention for Substance Abusers With Depressive Disorders), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Integrated Intervention for Substance Abusers With Depressive Disorders
Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Relative and Interactive Associations of Psychosocial Intervention and Alcoholics Anonymous Attendance With Alcohol Use Disorder Outcomes.Journal of studies on alcohol and drugs · 2023Trial
- Integrating a Brief Behavioral Intervention Into Case Management for Mothers With Perinatal Substance Use Disorder: Nonrandomized Pilot Feasibility Study.JMIR formative research · 2025Article
- Patterns and temporal change of psychopathological symptoms among inpatients with alcohol use disorder undergoing a twelve-step based treatment.Addictive behaviors reports · 2020Article
- Integrated Bio-behavioral Approach to Improve Adherence to Pre-exposure Prophylaxis and Reduce HIV Risk in People Who Use Drugs: A Pilot Feasibility Study.AIDS and behavior · 2018Article
- Changes in depression mediate the effects of AA attendance on alcohol use outcomes.The American journal of drug and alcohol abuse · 2018Article
- Developing an Integrated, Brief Biobehavioral HIV Prevention Intervention for High-Risk Drug Users in Treatment: The Process and Outcome of Formative Research.Frontiers in immunology · 2017Article
- The Influence of Neurocognitive Impairment on HIV Risk Behaviors and Intervention Outcomes among High-Risk Substance Users: A Systematic Review.Frontiers in public health · 2016Review
- Effects of long-term AA attendance and spirituality on the course of depressive symptoms in individuals with alcohol use disorder.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2015Article
- Mediated and moderated effects of neurocognitive impairment on outcomes of treatment for substance dependence and major depression.Journal of consulting and clinical psychology · 2014Article
- Psychiatric comorbidity and 12-step participation: a longitudinal investigation of treated young adults.Alcoholism, clinical and experimental research · 2014Article
- 12-step affiliation and attendance following treatment for comorbid substance dependence and depression: a latent growth curve mediation model.Substance abuse · 2013Article
- Developing and validation of identifying people in risk of addiction questionnaire (I.p.R.a).International journal of high risk behaviors & addiction · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
aimsAmong patients with substance dependence and comorbid major depressive disorder (MDD) receiving treatment in a controlled trial, we examined if group differences in depression were mediated by 12-Step involvement, and if the effects of 12-Step involvement on future alcohol and drug use were mediated by reductions in depression.
designControlled trial of Twelve-Step facilitation (TSF) and integrated cognitive-behavioral therapy (ICBT), delivered in out-patient groups for 6 months with adjunct pharmacotherapy.
settingOut-patient dual diagnosis clinic in Veteran's Affairs Healthcare Center.
participantsVeterans (n = 209) diagnosed with alcohol, stimulant or marijuana dependence and substance-independent MDD. MEASUREMENTS: Twelve-Step attendance and affiliation, depression severity, percentage of days drinking and percentage of days using drugs assessed at baseline and months 3, 6 and 9.
findingsIn multi-level analyses greater 12-Step meeting attendance predicted lower depression and mediated the superior depression outcomes of the TSF group, explaining 24.3% of the group difference in depression. Independent of treatment group, lower depression severity predicted lower future alcohol use and mediated the effects of 12-Step meetings, explaining 15.7% of their effects on future drinking. Controlled, lagged models indicated these effects were not confounded by current substance use, suggesting that depression had unique associations with 12-Step meeting attendance and future drinking.
conclusionsFor patients with substance dependence and major depressive disorder, attendance at 12-Step meetings is associated with mental health benefits that extend beyond substance use, and reduced depression could be a key mechanism whereby 12-Step meetings reduce future drinking in this population.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.