ArticleBreast cancer research : BCR2012
Potential for the embryonic morphogen Nodal as a prognostic and predictive biomarker in breast cancer.
Article in Breast cancer research : BCR, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed, 69 citations in OpenAlex.
- Proteomics Analysis of Polyphyllin D-Treated Triple-Negative Breast Cancer Cells Reveal the Anticancer Mechanisms of Polyphyllin D.Applied biochemistry and biotechnology · 2024Article
- Normal Skin Cells Increase Aggressiveness of Cutaneous Melanoma by Promoting Epithelial-to-Mesenchymal Transition via Nodal and Wnt Activity.International journal of molecular sciences · 2021Article
- Role ofMolecular biology research communications · 2021Article
- Genetically-encoded discovery of proteolytically stable bicyclic inhibitors for morphogen NODAL.Chemical science · 2021Article
- Embryonic protein NODAL regulates the breast tumor microenvironment by reprogramming cancer-derived secretomes.Neoplasia (New York, N.Y.) · 2021Article
- Increasing Embryonic Morphogen Nodal Expression Suggests Malignant Transformation in Colorectal Lesions and as a Potential Marker for CMS4 Subtype of Colorectal Cancer.Pathology oncology research : POR · 2021Article
- Combinatorial Strategies to Target Molecular and Signaling Pathways to Disarm Cancer Stem Cells.Frontiers in oncology · 2021Review
- Nodal is involved in chemoresistance of renal cell carcinoma cells via regulation of ABCB1.Journal of Cancer · 2021Article
- Review
- Translational control of breast cancer plasticity.Nature communications · 2020Article
- Influence of Nodal signalling on pluripotency factor expression, tumour cell proliferation and cisplatin-sensitivity in testicular germ cell tumours.BMC cancer · 2020Article
- Aberrantly Expressed Embryonic Protein NODAL Alters Breast Cancer Cell Susceptibility to γδ T Cell Cytotoxicity.Frontiers in immunology · 2020Article
- MNK1/NODAL Signaling Promotes Invasive Progression of Breast Ductal CarcinomaCancer research · 2019Article
- Article
- Nodal Promotes the Migration and Invasion of Bladder Cancer Cells via Regulation of Snail.Journal of Cancer · 2019Article
- Targeting the Stem Cell Properties of Adult Breast Cancer Cells: Using Combinatorial Strategies to Overcome Drug Resistance.Current molecular biology reports · 2017Article
- Targeting melanoma with front-line therapy does not abrogate Nodal-expressing tumor cells.Laboratory investigation; a journal of technical methods and pathology · 2017Article
- Nodal signaling promotes vasculogenic mimicry formation in breast cancer via the Smad2/3 pathway.Oncotarget · 2016Article
- Nodal expression in triple-negative breast cancer: Cellular effects of its inhibition following doxorubicin treatment.Cell cycle (Georgetown, Tex.) · 2016Article
- Plasticity underlies tumor progression: role of Nodal signaling.Cancer metastasis reviews · 2016Article
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12 authors at 4 institutions in 1 country.
Funding
Abstract
introductionThe re-emergence of the tumour growth factor-beta (TGF-beta)-related embryonic morphogen Nodal has recently been reported in several different human cancers. In this study, we examined the expression of Nodal in a series of benign and malignant human breast tissues to determine the clinical significance of this expression and whether Nodal could represent a potential therapeutic target in breast cancer.
methodsTissue sections from 431 therapeutically naive patients diagnosed with benign or malignant breast disease were stained for Nodal by immunohistochemistry and analysed in a blinded manner. The degree of Nodal staining was subsequently correlated with available clinical data, such as diagnoses and disease stage. These tissue findings were further explored in breast cancer cell lines MDA-MB-231 and MDA-MB-468 treated with a Nodal blocking antibody to determine biological effects for target validation.
resultsA variable degree of Nodal staining was detected in all samples. The intensity of Nodal staining was significantly greater in undifferentiated, advanced stage, invasive breast cancer compared with benign breast disease or early stage breast cancer. Treatment of human breast cancer cells in vitro with Nodal blocking antibody significantly reduced proliferation and colony-forming ability in soft agar, concomitant with increased apoptosis.
conclusionsThese data suggest a potential role for Nodal as a biomarker for disease progression and a promising target for anti-Nodal therapy in breast cancer.
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