ArticleAging cell2012
Fibroblasts from long-lived mutant mice exhibit increased autophagy and lower TOR activity after nutrient deprivation or oxidative stress.
Article in Aging cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 53 citations in OpenAlex.
- Common and Uncommon Mouse Models of Growth Hormone Deficiency.Endocrine reviews · 2024Review
- Improving dermal fibroblast-to-epidermis communications and aging wound repair through extracellular vesicle-mediated delivery of Gstm2 mRNA.Journal of nanobiotechnology · 2024Article
- mTOR inhibition by AZD2014 alleviates BCR::ABL1 independent imatinib resistance through enhancing autophagy in CML resistant cells.American journal of cancer research · 2024Article
- Geroscience and pathology: a new frontier in understanding age-related diseases.Pathology oncology research : POR · 2024Review
- Endoplasmic Reticulum Stress and Its Impact on Adipogenesis: Molecular Mechanisms Implicated.Nutrients · 2023Review
- Targeting the biology of aging with mTOR inhibitors.Nature aging · 2023Review
- Keloid Nodule Metabolic Activity for Continuous Expansion.Plastic and reconstructive surgery. Global open · 2022Article
- Long-lived mice with reduced growth hormone signaling have a constitutive upregulation of hepatic chaperone-mediated autophagy.Autophagy · 2021Article
- Mouse models of growth hormone deficiency.Reviews in endocrine & metabolic disorders · 2021Review
- Age-related impairment of autophagy in cervical motor neurons.Experimental gerontology · 2021Article
- Flavin-Containing Monooxygenases Are Conserved Regulators of Stress Resistance and Metabolism.Frontiers in cell and developmental biology · 2021Article
- Article
- Cap-independent mRNA translation is upregulated in long-lived endocrine mutant mice.Journal of molecular endocrinology · 2019Article
- Rapamycin reduces mortality in acute-stage paraquat-induced toxicity in zebrafish.Singapore medical journal · 2019Article
- Cellular energetics and mitochondrial uncoupling in canine aging.GeroScience · 2019Article
- Article
- Gasotransmitter hydrogen sulfide signaling in neuronal health and disease.Biochemical pharmacology · 2018Review
- Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production.Cell metabolism · 2017Article
- Far-infrared suppresses skin photoaging in ultraviolet B-exposed fibroblasts and hairless mice.PloS one · 2017Article
- Impaired autophagy activity is linked to elevated ER-stress and inflammation in aging adipose tissue.Aging · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Previous work has shown that primary skin-derived fibroblasts from long-lived pituitary dwarf mutants resist the lethal effects of many forms of oxidative and nonoxidative stress. We hypothesized that increased autophagy may protect fibroblasts of Pit-1(dw/dw) (Snell dwarf) mice from multiple forms of stress. We found that dwarf-derived fibroblasts had higher levels of autophagy, using LC3 and p62 as markers, in response to amino acid deprivation, hydrogen peroxide, and paraquat. Fibroblasts from dwarf mice also showed diminished phosphorylation of mTOR, S6K, and 4EBP1, consistent with the higher levels of autophagy in these cells after stress. Similar results were also observed in fibroblasts from mutant mice lacking growth hormone receptor (GHRKO mice) after amino acid withdrawal. Our results suggested that increased autophagy, regulated by TOR-dependent processes, may contribute to stress resistance in fibroblasts from long-lived mutant mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.