ArticleBMC evolutionary biology2012
Immune genes undergo more adaptive evolution than non-immune system genes in Daphnia pulex.
Article in BMC evolutionary biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
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- The molecular evolution of cancer associated genes in mammals.Scientific reports · 2024Article
- Repeated horizontal acquisition of lagriamide-producing symbionts in Lagriinae beetles.The ISME journal · 2024Article
- Non-MHC immunity genes do not affect parasite load in European invasive populations of common raccoon.Scientific reports · 2023Article
- Signature selection forces and evolutionary divergence of immune-survival genes compared between two important shrimp species.PloS one · 2023Article
- Complex patterns shape immune genes diversity during invasion of common raccoon in Europe - Selection in action despite genetic drift.Evolutionary applications · 2023Article
- Population-Genomic Analysis Identifies a Low Rate of Global Adaptive Fixation in the Proteins of the Cyclical Parthenogen Daphnia magna.Molecular biology and evolution · 2022Article
- Adaptive Evolution in TRIF Leads to Discordance between Human and Mouse Innate Immune Signaling.Genome biology and evolution · 2021Article
- Sequence Diversity, Locus Structure, and Evolutionary History of theFrontiers in immunology · 2021Article
- Speculations on the evolution of humoral adaptive immunity.Immunology and cell biology · 2020Review
- An assessment of the immune costs associated with meiotic drive elements inProceedings. Biological sciences · 2019Article
- Balancing Selection Drives the Maintenance of Genetic Variation in Drosophila Antimicrobial Peptides.Genome biology and evolution · 2019Article
- Insights into the Genomics of Clownfish Adaptive Radiation: Genetic Basis of the Mutualism with Sea Anemones.Genome biology and evolution · 2019Article
- Tissue specific alpha-2-Macroglobulin (A2M) splice isoform diversity in Hilsa shad, Tenualosa ilisha (Hamilton, 1822).PloS one · 2019Article
- Article
- Daphnia galeata responds to the exposure to an ichthyosporean gut parasite by down-regulation of immunity and lipid metabolism.BMC genomics · 2018Article
- Human long intrinsically disordered protein regions are frequent targets of positive selection.Genome research · 2018Article
- Rapid seasonal evolution in innate immunity of wildProceedings. Biological sciences · 2018Article
- β-defensins: An innate defense for bovine mastitis.Veterinary world · 2017Review
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4 authors.
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Abstract
backgroundUnderstanding which parts of the genome have been most influenced by adaptive evolution remains an unsolved puzzle. Some evidence suggests that selection has the greatest impact on regions of the genome that interact with other evolving genomes, including loci that are involved in host-parasite co-evolutionary processes. In this study, we used a population genetic approach to test this hypothesis by comparing DNA sequences of 30 putative immune system genes in the crustacean Daphnia pulex with 24 non-immune system genes.
resultsIn support of the hypothesis, results from a multilocus extension of the McDonald-Kreitman (MK) test indicate that immune system genes as a class have experienced more adaptive evolution than non-immune system genes. However, not all immune system genes show evidence of adaptive evolution. Additionally, we apply single locus MK tests and calculate population genetic parameters at all loci in order to characterize the mode of selection (directional versus balancing) in the genes that show the greatest deviation from neutral evolution.
conclusionsOur data are consistent with the hypothesis that immune system genes undergo more adaptive evolution than non-immune system genes, possibly as a result of host-parasite arms races. The results of these analyses highlight several candidate loci undergoing adaptive evolution that could be targeted in future studies.
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