ArticleJournal of photochemistry and photobiology. A, Chemistry2012
Di-Cysteine S,S-Tetrazine: A Potential Ultra-fast Photochemical Trigger to Explore the Early Events of Peptide/Protein Folding.
Article in Journal of photochemistry and photobiology. A, Chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed.
- Sulfur-tetrazine as highly efficient visible-light activatable photo-trigger for designing photoactivatable fluorescence biomolecules.Journal of materials chemistry. B · 2024Article
- Article
- Advanced Multifunctional Hydrogels for Enhanced Wound Healing through Ultra-Fast Selenol-SAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
- Rational Design for High Bioorthogonal Fluorogenicity of Tetrazine-Encoded Green Fluorescent Proteins.Natural sciences (Weinheim, Germany) · 2022Article
- Photo-initiated rupture of azobenzene micelles to enable the spectroscopic analysis of antimicrobial peptide dynamics.RSC advances · 2020Article
- Tetrazine as a general phototrigger to turn on fluorophores.Chemical science · 2020Article
- S,S-Tetrazine-Based Hydrogels with Visible Light Cleavable Properties for On-Demand Anticancer Drug Delivery.Research (Washington, D.C.) · 2020Article
- Arylation Chemistry for Bioconjugation.Angewandte Chemie (International ed. in English) · 2019Review
- Applications of two-dimensional infrared spectroscopy.The Analyst · 2015Review
- Peptide/protein stapling and unstapling: introduction of s-tetrazine, photochemical release, and regeneration of the peptide/protein.Journal of the American Chemical Society · 2015Article
- The design and synthesis of alanine-rich α-helical peptides constrained by an S,S-tetrazine photochemical trigger: a fragment union approach.The Journal of organic chemistry · 2014Article
- Nonequilibrium dynamics of helix reorganization observed by transient 2D IR spectroscopy.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Design, synthesis, and photochemical validation of peptide linchpins containing the S,S-tetrazine phototrigger.Organic letters · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The tetrazine chromophore holds promise as an effective photochemical trigger to achieve structural release, directed at the determination of peptide/protein motions that occur early in the folding processes. The photochemistry of 3,6-di-cysteine-S,S-tetrazines was examined by femtosecond IR transient absorption spectroscopy. Excitation of the tetrazine chromophore by visible and near UV light in the end yields chemically inert, structurally unobtrusive photoproducts that are not expected to interfere with the conformational dynamics of peptides and proteins. Dicysteine S,S-tetrazine is suggested to undergo photocleavage via a photochemical pathway different than the parent molecule s-tetrazine, based on kinetic measurements that reveal a stepwise reaction pathway of photofragmentation, whereby the initial ring cleavage event occurs prior to the formation of the SCN groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.