Evidence map›Paper›PMID 22577210›Full record

ReviewThe Journal of infectious diseases2012

The biology of atherosclerosis: general paradigms and distinct pathogenic mechanisms among HIV-infected patients.

Janet Lo, Jorge Plutzky

Open access · bronzeAbstract readReview
In one paragraph

Review in The Journal of infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Brief Report: Statin Effects on Myocardial Fibrosis Markers in People Living With HIV.Journal of acquired immune deficiency syndromes (1999) · 2018
    Trial
  4. Trial
  5. Article
  6. Review
  7. Deficiency of Caspase-1 Attenuates HIV-1-Associated Atherogenesis in Mice.International journal of molecular sciences · 2023
    Article
  8. Article
  9. Article
  10. Observational
  11. The role of multimodality imaging in HIV-related heart disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  12. Review
  13. Observational
  14. Article
  15. Article
  16. Article
  17. Article
  18. Cardiovascular Disease, Statins, and HIV.The Journal of infectious diseases · 2016
    Review
  19. Inflammation, immune activation, and cardiovascular disease in HIV.AIDS (London, England) · 2016 · on this map
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Janet LoProgram in Nutritional Metabolism, Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit St., Boston, MA 02114, USA.
Jorge Plutzky
Brigham and Women's Hospital · USHarvard University · US

Funding

Tissue AnalysesP01HL048743 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHEL, THOMAS · 1992 to 2014
$26.3M
Atherosclerosis and Inflammation in HIV DiseaseK23HL092792 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LO, JANET · 2008 to 2012
$705k
NHLBI NIH HHS K23 HL092792NHLBI NIH HHS P01 HL048743NHLBI NIH HHS R01 HL048743
6 · The paper itself

Abstract

Complications of atherosclerosis, including myocardial infarction and stroke, are the leading cause of death and disability worldwide. Recent data strongly implicate cardiovascular death as a contributor to mortality among patients with human immunodeficiency virus (HIV) infection, with evidence suggesting increased incidence of atherosclerosis among these patients. Therefore, greater understanding of atherosclerotic mechanisms and how these responses may be similar or distinct in HIV-infected patients is needed. Key concepts in atherosclerosis are reviewed, including the evidence that inflammation and abnormal metabolism are major drivers of atherosclerosis, and connected to the current literature regarding atherosclerosis in the context of HIV.

Indexed as

AtherosclerosisHIV InfectionsHumansInflammationViral Load

Identifiers

PMID22577210
PMCPMC3349296
OpenAlexW2106191596

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.