Trial reportPhysical therapy2012
A combined early cognitive and physical rehabilitation program for people who are critically ill: the activity and cognitive therapy in the intensive care unit (ACT-ICU) trial.
Trial report in Physical therapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 29 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ACT-ICU Study: Activity and Cognitive Therapy in the Intensive Care Unit
Virtual Reality Stimulation to Enhance Cognitive Function of Intensive Care Unit Patients
Safety, Tolerability, and Early Efficacy of Immersive Virtual Reality for Early Neurocognitive Stimulation in the Intensive Care Unit.
Who cites it
29 citing papers in PubMed, 5 syntheses or guidelines pooled it, 106 citations in OpenAlex.
- The effect of virtual reality stimulation on reducing the incidence of delirium among patients admitted to intensive care units: a systematic review study.BMC anesthesiology · 2025Pooled it
- Pooled it
- Interventions for preventing intensive care unit delirium in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Impact of follow-up consultations for ICU survivors on post-ICU syndrome: a systematic review and meta-analysis.Intensive care medicine · 2015Pooled it
- Safety criteria to start early mobilization in intensive care units. Systematic review.Revista Brasileira de terapia intensivaPooled it
- Visuo-acoustic stimulation that helps you to relax: A virtual reality setup for patients in the intensive care unit.Scientific reports · 2017Trial
- The physical function intensive care test: implementation in survivors of critical illness.Physical therapy · 2014Trial
- Feasibility and safety of early combined cognitive and physical therapy for critically ill medical and surgical patients: the Activity and Cognitive Therapy in ICU (ACT-ICU) trial.Intensive care medicine · 2014Trial
- Trial
- Physical Therapist-Led Therapeutic Exercise and Mobility in Adult Intensive Care Units: A Scoping Review of Operational Definitions, Dose Progression, Safety, and Documentation.Journal of clinical medicine · 2025Review
- Assessing the safety of physical rehabilitation in critically ill patients: a Delphi study.Critical care (London, England) · 2024Article
- Lessons from a review of physiotherapy and psychological rehabilitation received during ICU stay and beyond to inform the development of an ICU follow clinic.Journal of the Intensive Care Society · 2022Article
- Early Mobilization in the ICU: A Collaborative, Integrated Approach.Critical care explorations · 2020Article
- The Association of a Frailty Index and Incident Delirium in Older Hospitalized Patients: An Observational Cohort Study.Clinical interventions in aging · 2020Observational
- Early Mobilization Interventions in the Intensive Care Unit: Ongoing and Unpublished Randomized Trials.Critical care research and practice · 2020Article
- Comparing the Relaxing Effects of Different Virtual Reality Environments in the Intensive Care Unit: Observational Study.JMIR perioperative medicine · 2019Article
- Cognitive Deficits Following Intensive Care.Deutsches Arzteblatt international · 2019Review
- Perception and Performance on a Virtual Reality Cognitive Stimulation for Use in the Intensive Care Unit: A Non-randomized Trial in Critically Ill Patients.Frontiers in medicine · 2019Article
- Sepsis Survivors Admitted to Skilled Nursing Facilities: Cognitive Impairment, Activities of Daily Living Dependence, and Survival.Critical care medicine · 2018Article
- Resilience in Survivors of Critical Illness in the Context of the Survivors' Experience and Recovery.Annals of the American Thoracic Society · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIn the coming years, the number of survivors of critical illness is expected to increase. These survivors frequently develop newly acquired physical and cognitive impairments. Long-term cognitive impairment is common following critical illness and has dramatic effects on patients' abilities to function autonomously. Neuromuscular weakness affects similar proportions of patients and leads to equally profound life alterations. As knowledge of these short-term and long-term consequences of critical illness has come to light, interventions to prevent and rehabilitate these devastating consequences have been sought. Physical rehabilitation has been shown to improve functional outcomes in people who are critically ill, but subsequent studies of physical rehabilitation after hospital discharge have not. Post-hospital discharge cognitive rehabilitation is feasible in survivors of critical illness and is commonly used in people with other forms of acquired brain injury. The feasibility of early cognitive therapy in people who are critically ill remains unknown.
objectiveThe purpose of this novel protocol trial will be to determine the feasibility of early and sustained cognitive rehabilitation paired with physical rehabilitation in patients who are critically ill from medical and surgical intensive care units.
designThis is a randomized controlled trial.
settingThe setting for this trial will be medical and surgical intensive care units of a large tertiary care referral center. PATIENTS: The participants will be patients who are critically ill with respiratory failure or shock.
interventionPatients will be randomized to groups receiving usual care, physical rehabilitation, or cognitive rehabilitation plus physical rehabilitation. Twice-daily cognitive rehabilitation sessions will be performed with patients who are noncomatose and will consist of orientation, memory, and attention exercises (eg, forward and reverse digit spans, matrix puzzles, letter-number sequences, pattern recognition). Daily physical rehabilitation sessions will advance patients from passive range of motion exercises through ambulation. Patients with cognitive or physical impairment at discharge will undergo a 12-week, in-home cognitive rehabilitation program. MEASUREMENTS: A battery of neurocognitive and functional outcomes will be measured 3 and 12 months after hospital discharge.
conclusionsIf feasible, these interventions will lay the groundwork for a larger, multicenter trial to determine their efficacy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.