ArticleAJNR. American journal of neuroradiology2012
Severe traumatic head injury: prognostic value of brain stem injuries detected at MRI.
Article in AJNR. American journal of neuroradiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic value of computed tomography and magnetic resonance imaging findings in acute traumatic brain injury in prediction of poor neurological outcome and mortality: a systematic review and meta-analysis.Neurosurgical review · 2024Pooled it
- Trial
- Non-contrast computed tomography at the end of the acute care phase as an additional prognostic tool after aneurysmal subarachnoid hemorrhage.Neurosurgical review · 2026Article
- Clinical Performance of Quantitative Susceptibility Mapping in Cerebral Microbleed Detection Relative to 2D GRE.Clinical neuroradiology · 2025Article
- Parkinsonism associated with prolonged unresponsive wakefulness syndrome after blunt head injury: a clinico-pathological study.Free neuropathology · 2025Article
- Long-Term Outcomes in Severe Traumatic Brain Injury and Associated Factors: A Prospective Cohort Study.Journal of clinical medicine · 2022Article
- Diffuse Axonal Injury Grade on Early MRI is Associated with Worse Outcome in Children with Moderate-Severe Traumatic Brain Injury.Neurocritical care · 2022Article
- In vivo estimates of axonal stretch and 3D brain deformation during mild head impact.Brain multiphysics · 2020Article
- Brainstem Diffuse Axonal Injury and Consciousness.Journal of clinical imaging science · 2019Article
- Prognosis of diffuse axonal injury with traumatic brain injury.The journal of trauma and acute care surgery · 2018Article
- "Don't lose hope early": Hemorrhagic diffuse axonal injury on head computed tomography is not associated with poor outcome in moderate to severe traumatic brain injury patients.The journal of trauma and acute care surgery · 2018Observational
- Extended Anatomical Grading in Diffuse Axonal Injury Using MRI: Hemorrhagic Lesions in the Substantia Nigra and Mesencephalic Tegmentum Indicate Poor Long-Term Outcome.Journal of neurotrauma · 2017Article
- Imaging Evaluation of Acute Traumatic Brain Injury.Neurosurgery clinics of North America · 2016Review
- Regional volumes in brain stem and cerebellum are associated with postural impairments in young brain-injured patients.Human brain mapping · 2015Article
- Use of multisequence 3.0-T MRI to detect severe traumatic brain injury and predict the outcome.The British journal of radiology · 2015Article
- Traumatic brain stem injury: evaluation by MRI. Author reply.AJNR. American journal of neuroradiology · 2013Article
- Traumatic brain stem injury: evaluation by MRI.AJNR. American journal of neuroradiology · 2013Article
- Parent perceptions of early prognostic encounters following children's severe traumatic brain injury: 'locked up in this cage of absolute horror'.Brain injury · 2013Article
- Prognostic value of early magnetic resonance imaging in dogs after traumatic brain injury: 50 cases.Journal of veterinary internal medicineArticle
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
background and purposeTraumatic brain injuries represent an important cause of death for young people. The main objectives of this work are to correlate brain stem injuries detected at MR imaging with outcome at 6 months in patients with severe TBI, and to determine which MR imaging findings could be related to a worse prognosis. MATERIALS AND
methodsOne hundred and eight patients with severe TBI were studied by MR imaging in the first 30 days after trauma. Brain stem injury was categorized as anterior or posterior, hemorrhagic or nonhemorrhagic, and unilateral or bilateral. Outcome measures were GOSE and Barthel Index 6 months postinjury. The relationship between MR imaging findings of brain stem injuries, outcome, and disability was explored by univariate analysis. Prognostic capability of MR imaging findings was also explored by calculation of sensitivity, specificity, and area under the ROC curve for poor and good outcome.
resultsBrain stem lesions were detected in 51 patients, of whom 66% showed a poor outcome, as expressed by the GOSE scale. Bilateral involvement was strongly associated with poor outcome (P < .05). Posterior location showed the best discriminatory capability in terms of outcome (OR 6.8, P < .05) and disability (OR 4.8, P < .01). The addition of nonhemorrhagic and anterior lesions or unilateral injuries showed the highest odds and best discriminatory capacity for good outcome.
conclusionsThe prognosis worsens in direct relationship to the extent of traumatic injury. Posterior and bilateral brain stem injuries detected at MR imaging are poor prognostic signs. Nonhemorrhagic injuries showed the highest positive predictive value for good outcome.
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