Trial reportEuropean journal of pediatrics2012
Specific oral desensitization in children with IgE-mediated cow's milk allergy. Evolution in one year.
Trial report in European journal of pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Oral immunotherapy for milk allergy.The Cochrane database of systematic reviews · 2012Pooled it
- Immune tolerance platforms to mitigate unwanted immune responses.Journal of pharmaceutical sciences · 2026Review
- IgE and IgG4 Epitope Mapping of Food Allergens with a Peptide Microarray Immunoassay.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Oral tolerance as antigen-specific immunotherapy.Immunotherapy advances · 2021Review
- Oral Immunotherapy for Cow’s Milk Allergy: Five Years’ Experience from a Single Center in TurkeyBalkan medical journal · 2020Article
- Oral and Sublingual Immunotherapy for Treatment of IgE-Mediated Food Allergy.Clinical reviews in allergy & immunology · 2018Review
- Current Status of Potential Therapies for IgE-Mediated Food Allergy.Current allergy and asthma reports · 2018Review
- Oral Food Desensitization in Children With IgE-Mediated Cow's Milk Allergy: Immunological Changes Underlying Desensitization.Allergy, asthma & immunology research · 2017Article
- Sublingual (SLIT) versus oral immunotherapy (OIT) for food allergy.Current allergy and asthma reports · 2014Review
- Emerging therapies for food allergy.The Journal of clinical investigation · 2014Review
- Use of IgE and IgG4 epitope binding to predict the outcome of oral immunotherapy in cow's milk allergy.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2014Article
- Review
- Milk oral immunotherapy-effective but still experimental.European journal of pediatrics · 2013Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledCow's milk allergy is the most frequent childhood food allergy. Children older than 5 who have not become tolerant have less probabilities of natural tolerance. Specific oral desensitization methods are being investigated in reference centres. The aims of our study were to assess the efficacy of our guideline of specific oral desensitization to cow's milk in children and to know its suitability for anaphylactic children. Both clinical and specific IgE outcomes were evaluated. Eighty-seven children aged 5 to 16 years with a history of cow's milk allergy were included. Prior to desensitization, skin prick test, specific IgE to cow's milk proteins and a double-blind placebo control food challenge were performed in all. Of the 87 patients, 21 had a negative challenge; they were considered tolerant, and they were told to follow a free diet. Of the positive, 44 were anaphylactic and 22 non-anaphylactic. All of them were included. In non-anaphylactic patients, 6 achieved partial and 16 maximum desensitization after 23.1 weeks. In the anaphylactic group, 7 achieved partial and 35 maximum desensitization after 26.4 weeks. Cow's milk-specific IgE levels and casein-specific IgE levels were significantly lower in the tolerant patients at baseline. One year after desensitization, the medium specific cow's milk levels and casein IgE levels had dropped significantly.
conclusionsOur guideline for specific oral desensitization to cow's milk is efficacious even in patients with anaphylactic reactions to cow's milk and represents a significant life change. Immunological changes in 1 year show a drop in cow's milk protein-specific IgE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.