Evidence map›Paper›PMID 22576754›Full record

ReviewNeuroendocrinology2012

The Buzz about anabolic androgenic steroids: electrophysiological effects in excitable tissues.

Joseph G Oberlander, Carlos A A Penatti, Donna M Porter, Leslie P Henderson

Open access · bronzeAbstract readReview
In one paragraph

Review in Neuroendocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Joseph G OberlanderDepartment of Physiology and Neurobiology, The Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
Carlos A A Penatti
Donna M Porter
Leslie P Henderson
Dartmouth College · USUniversidade Nove de Julho · BR

Funding

Steroid Regulation of Ion ChannelsR01DA014137 · NIDA · DARTMOUTH COLLEGE · PI HENDERSON, LESLIE P · 2001 to 2011
$3.0M
THE ROLE OF HORMONES IN HEALTH AND DISEASET32DK007508 · NIDDK · DARTMOUTH COLLEGE · PI NORTH, WILLIAM G · 1986 to 2011
$2.5M
Interactions of Anabolic Steroids and Stress Hormones in the ForebrainR03DA022716 · NIDA · DARTMOUTH COLLEGE · PI HENDERSON, LESLIE P · 2007 to 2008
$151k
NIDA NIH HHS DA014137NIDA NIH HHS DA022716NIDA NIH HHS R01 DA014137NIDA NIH HHS R03 DA022716NIDDK NIH HHS DK07508NIDDK NIH HHS T32 DK007508
6 · The paper itself

Abstract

Anabolic androgenic steroids (AAS) comprise a large and growing class of synthetic androgens used clinically to promote tissue-building in individuals suffering from genetic disorders, injuries, and diseases. Despite these beneficial therapeutic applications, the predominant use of AAS is illicit: these steroids are self-administered to promote athletic performance and body image. Hand in hand with the desired anabolic actions of the AAS are untoward effects on the brain and behavior. While the signaling routes by which the AAS impose both beneficial and harmful actions may be quite diverse, key endpoints are likely to include ligand-gated and voltage-dependent ion channels that govern the activity of electrically excitable tissues. Here, we review the known effects of AAS on molecular targets that play critical roles in controlling electrical activity, with a specific focus on the effects of AAS on neurotransmission mediated by GABA(A) receptors in the central nervous system.

Indexed as

Anabolic AgentsAnimalsBrainHumansIon ChannelsNeuronsReceptors, GABA-ASteroidsSynaptic TransmissionTestosterone CongenersAnabolic AgentsIon ChannelsReceptors, GABA-ASteroidsTestosterone Congeners

Identifiers

PMID22576754
PMCPMC3488447
OpenAlexW2035247282

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.