Evidence map›Paper›PMID 22576662›Full record

ArticleCell death and differentiation2012

Thyroid hormone receptors promote metastasis of human hepatoma cells via regulation of TRAIL.

H-C Chi, S-L Chen, C-J Liao, C-H Liao, M-M Tsai, Y-H Lin, Y-H Huang, C-T Yeh, S-M Wu, Y-H Tseng and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death and differentiation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 33 citations in OpenAlex.

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  19. Thyroid hormone actions in liver cancer.Cellular and molecular life sciences : CMLS · 2013
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

H-C ChiDepartment of Biochemistry, School of Medicine, Chang-Gung University, Taoyuan, Taiwan.
S-L Chen
C-J Liao
C-H Liao
M-M Tsai
Y-H Lin
Y-H Huang
C-T Yeh
S-M Wu
Y-H Tseng
C-Y Chen
C-Y Tsai
I-H Chung
W-J Chen
K-H Lin
Chang Gung University · TWChang Gung Memorial Hospital · TWChang Gung University of Science and Technology · TWNational Central University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although accumulating evidence has confirmed the important roles of thyroid hormone (T(3)) and its receptors (TRs) in tumor progression, the specific functions of TRs in carcinogenesis remain unclear. In the present study, tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) was directly upregulated by T(3) in TR-overexpressing hepatoma cell lines. TRAIL is an apoptotic inducer, but it can nonetheless trigger non-apoptotic signals favoring tumorigenesis in apoptosis-resistant cancer cells. We found that TR-overexpressing hepatoma cells treated with T(3) were apoptosis resistant, even when TRAIL was upregulated. This apoptotic resistance may be attributable to simultaneous upregulation of Bcl-xL by T(3), because (1) knockdown of T(3)-induced Bcl-xL expression suppressed T(3)-mediated protection against apoptosis, and (2) overexpression of Bcl-xL further protected hepatoma cells from TRAIL-induced apoptotic death, consequently leading to TRAIL-promoted metastasis of hepatoma cells. Moreover, T(3)-enhanced metastasis in vivo was repressed by the treatment of TRAIL-blocking antibody. Notably, TRAIL was highly expressed in a subset of hepatocellular carcinoma (HCC) patients, and this high-level expression was significantly correlated with that of TRs in these HCC tissues. Together, our findings provide evidence for the existence of a novel mechanistic link between increased TR and TRAIL levels in HCC. Thus, TRs induce TRAIL expression, and TRAIL thus synthesized acts in concert with simultaneously synthesized Bcl-xL to promote metastasis, but not apoptosis.

Indexed as

Neoplasm MetastasisAnimalsApoptosisbcl-X ProteinCarcinoma, HepatocellularCell Line, TumorHep G2 CellsHumansLiver NeoplasmsMatrix Metalloproteinase 2Matrix Metalloproteinase 7Matrix Metalloproteinase 9MiceMice, SCIDReceptors, Thyroid HormoneTNF-Related Apoptosis-Inducing Ligandbcl-X ProteinMatrix Metalloproteinase 2Matrix Metalloproteinase 7Matrix Metalloproteinase 9Receptors, Thyroid HormoneTNF-Related Apoptosis-Inducing LigandTriiodothyronine

Identifiers

PMID22576662
PMCPMC3469053
OpenAlexW2095223063

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.