ArticleBritish journal of cancer2012
Hypertensive diseases in pregnancy and breast cancer risk.
Article in British journal of cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- BCL2A1‑ and G0S2‑driven neutrophil extracellular traps: A protective mechanism linking preeclampsia to reduced breast cancer risk.Oncology reports · 2025Article
- Association of Pregnancy Complications with Endometrial or Ovarian or Breast Cancer: A Case Control Study.Medicina (Kaunas, Lithuania) · 2024Article
- Causal effects of hypertensive disorders of pregnancy on future gynecologic tumors: A two-sample Mendelian randomization study.Cancer medicine · 2024Article
- Hypertensive conditions of pregnancy, preterm birth, and premenopausal breast cancer risk: a premenopausal breast cancer collaborative group analysis.Breast cancer research and treatment · 2023Article
- A common IGF1R gene variant predicts later life breast cancer risk in women with preeclampsia.Breast cancer research and treatment · 2023Article
- Hypertensive diseases of pregnancy and risk of breast cancer in the Black Women's Health Study.Breast cancer research and treatment · 2022Article
- Article
- Real-World Data Analysis of Pregnancy-Associated Breast Cancer at a Tertiary-Level Hospital in Romania.Medicina (Kaunas, Lithuania) · 2020Article
- Pregnancy Hypertension and a Commonly Inherited IGF1R Variant (rs2016347) Reduce Breast Cancer Risk by Enhancing Mammary Gland Involution.Journal of oncology · 2019Article
- Pregnancy complications and subsequent breast cancer risk in the mother: a Nordic population-based case-control study.International journal of cancer · 2018Article
- Breast cancer risk in relation to history of preeclampsia and hyperemesis gravidarum: Prospective analysis in the Generations Study.International journal of cancer · 2018Article
- Inherited factors contribute to an inverse association between preeclampsia and breast cancer.Breast cancer research : BCR · 2018Article
- Functional IGF1R variant predicts breast cancer risk in women with preeclampsia in California Teachers Study.Cancer causes & control : CCC · 2017Article
- Epidemiology of hypertensive disorders in pregnancy: prevalence, risk factors, predictors and prognosis.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Review
- A prospective study of angiogenic markers and postmenopausal breast cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial.Cancer causes & control : CCC · 2016Article
- Comment on: 'Hypertensive diseases in pregnancy and breast cancer risk'.British journal of cancer · 2016Article
- Maternal Preeclampsia and Androgens in the Offspring around Puberty: A Follow-Up Study.PloS one · 2016Article
- First pregnancy events and future breast density: modification by age at first pregnancy and specific VEGF and IGF1R gene variants.Cancer causes & control : CCC · 2014Article
- Pregnancy-related characteristics and breast cancer risk.Cancer causes & control : CCC · 2013Article
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypertensive diseases in pregnancy may be associated with a reduced risk of breast cancer. Most previous studies are small and have shown conflicting results.
methodsIn a cohort of 919 712 women who gave their first birth between 1967 and 2008, with linkage of information from two national registries, we assessed whether women with pregnancy hypertensive diseases are at reduced breast cancer risk. We used Cox regression to estimate hazard ratios (HRs) with 95% confidence intervals (CI).
resultsCompared with women with a normotensive first pregnancy, women with hypertension or preeclampsia in their first pregnancy had a reduced breast cancer risk (HR 0.83, 95% CI 0.77, 0.90). A reduced risk was consistently observed for hypertensive disease in any pregnancy, for recurrent hypertensive disease in pregnancy, and before and after 50 years of age at breast cancer diagnosis. The association was strongest for women with hypertension in pregnancy, who delivered at term/post-term (HR 0.81, 95% CI 0.75, 0.88) or had a child of average birth weight (HR 0.77, 95% CI 0.69, 0.85).
conclusionWomen with pregnancy hypertensive diseases are at reduced breast cancer risk. Whether this association can be attributed to pregnancy-specific events or to underlying biological traits remains unclear.
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