ReviewPflugers Archiv : European journal of physiology2013
Control of renin [corrected] gene expression.
Review in Pflugers Archiv : European journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Four-week inhibition of the renin-angiotensin system in spontaneously hypertensive rats results in persistently lower blood pressure with reduced kidney renin and changes in expression of relevant gene networks.Cardiovascular research · 2024Article
- Polycystic kidneys: interaction of notch and renin.Clinical science (London, England : 1979) · 2023Article
- Under Pressure: A Baroreceptor Mechanism in the Renal Renin Cell Controlling Renin.Circulation research · 2021Article
- Article
- Genome-wide map of proximity linkage to renin proximal promoter in rat.Physiological genomics · 2018Article
- Vitamin A, endocrine tissues and hormones: interplay and interactions.Endocrine connections · 2017Article
- The PPAR-gamma-binding sequence Pal3 is necessary for basal but dispensable for high-fat diet regulated human renin expression in the kidney.Pflugers Archiv : European journal of physiology · 2017Article
- Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Estrogen Receptor α Is Required for Maintaining Baseline Renin Expression.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Vitamin D depletion aggravates hypertension and target-organ damage.Journal of the American Heart Association · 2015Article
- Classical Renin-Angiotensin system in kidney physiology.Comprehensive Physiology · 2014Review
- PPARgamma-Dependent Control of Renin Expression: Molecular Mechanisms and Pathophysiological Relevance.PPAR research · 2013Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Renin, as part of the renin-angiotensin system, plays a critical role in the regulation of blood pressure, electrolyte homeostasis, mammalian renal development, and progression of fibrotic/hypertrophic diseases. Renin gene transcription is subject to complex developmental and tissue-specific regulation. Initial studies using the mouse As4.1 cell line, which has many characteristics of the renin-expressing juxtaglomerular cells of the kidney, have identified a proximal promoter region (-197 to -50 bp) and an enhancer (-2,866 to -2,625 bp) upstream of the Ren-1(c) gene, which are critical for renin gene expression. The proximal promoter region contains several transcription factor binding sites including a binding site for the products of the developmental control genes Hox. The enhancer consists of at least 11 transcription factor binding sites and is responsive to various signal transduction pathways including cAMP, retinoic acid, endothelin-1, and cytokines, all of which are known to alter renin mRNA levels. Furthermore, in vivo models have validated several of these key components found within the proximal promoter region and the enhancer as well as other key sites necessary for renin gene transcription.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.