ArticleEnvironmental and molecular mutagenesis2012
Silver nanoparticle-induced mutations and oxidative stress in mouse lymphoma cells.
Article in Environmental and molecular mutagenesis, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 110 citations in OpenAlex.
- Tissue distribution, placental transfer and excretion of silver nanoparticles in pregnant rats after a single oral dose.Environmental analysis, health and toxicology · 2023Article
- The use of Trojan-horse drug delivery system in managing periodontitis.International dental journal · 2023Review
- A Current Perspective on the Potential of Nanomedicine for Anti-Tuberculosis Therapy.Tropical medicine and infectious disease · 2023Review
- Evaluation of silver nanoparticles in cosmeceutical and potential biosafety complications.Saudi journal of biological sciences · 2022Review
- Thymidine KinaseFrontiers in toxicology · 2022Article
- Hazard Assessment of Benchmark Metal-Based Nanomaterials Through a Set of In Vitro Genotoxicity Assays.Advances in experimental medicine and biology · 2022Article
- The mechanism of cell death induced by silver nanoparticles is distinct from silver cations.Particle and fibre toxicology · 2021Article
- Advances in Nanomaterials for Injured Heart Repair.Frontiers in bioengineering and biotechnology · 2021Review
- Metal/metal oxide nanoparticles: Toxicity concerns associated with their physical state and remediation for biomedical applications.Toxicology reports · 2021Review
- A proposed insight into the anti-viral potential of metallic nanoparticles against novel coronavirus disease-19 (COVID-19).Bulletin of the National Research Centre · 2021Review
- Roles of ROS and cell cycle arrest in the genotoxicity induced by gold nanorod core/silver shell nanostructure.Nanoscale research letters · 2020Article
- Detection of Loss of Heterozygosity in Tk-Deficient Mutants from L5178Y TkMethods in molecular biology (Clifton, N.J.) · 2020Article
- Cytotoxicity and Transcriptomic Analysis of Silver Nanoparticles in Mouse Embryonic Fibroblast Cells.International journal of molecular sciences · 2018Article
- Quantitative differentiation of whole smoke solution-induced mutagenicity in the mouse lymphoma assay.Environmental and molecular mutagenesis · 2018Article
- Role of omics techniques in the toxicity testing of nanoparticles.Journal of nanobiotechnology · 2017Review
- The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles.International journal of molecular sciences · 2017Review
- Comparative oxidative stress elicited by nanosilver in stableToxicology research · 2016Article
- Biomarkers of susceptibility: State of the art and implications for occupational exposure to engineered nanomaterials.Toxicology and applied pharmacology · 2016Review
- Quantitative analysis of the relative mutagenicity of five chemical constituents of tobacco smoke in the mouse lymphoma assay.Mutagenesis · 2016Article
- Genotoxic effects of synthetic amorphous silica nanoparticles in the mouse lymphoma assay.Toxicology reports · 2016Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Silver nanoparticles (Ag-NPs) have increasingly been used for coatings on various textiles and certain implants, for the treatment of wounds and burns, as a water disinfectant, and in air-freshener sprays. The wide use of Ag-NPs may have potential human health impacts. In this study, the mutagenicity of 5-nm Ag-NPs was evaluated in the mouse lymphoma assay system, and modes of action were assessed using standard alkaline and enzyme-modified Comet assays and gene expression analysis. Treatments of L5178Y/Tk(+/-) mouse lymphoma cells with 5-nm uncoated Ag-NPs resulted in a significant yield of mutants at doses between 3 and 6 μg/mL; the upper range was limited by toxicity. Loss of heterozygosity analysis of the Tk mutants revealed that treatments with uncoated Ag-NPs induced mainly chromosomal alterations spanning less than 34 megabase pairs on chromosome 11. Although no significant induction of DNA damage in Ag-NP-treated mouse lymphoma cells was observed in the standard Comet assay, the Ag-NP treatments induced a dose-responsive increase in oxidative DNA damage in the enzyme-modified Comet assay in which oxidative lesion-specific endonucleases were added. Gene expression analysis using an oxidative stress and antioxidant defense polymerase chain reaction (PCR) array showed that the expressions of 17 of the 59 genes on the arrays were altered in the cells treated with Ag-NPs. These genes are involved in production of reactive oxygen species, oxidative stress response, antioxidants, oxygen transporters, and DNA repair. These results suggest that 5 nm Ag-NPs are mutagenic in mouse lymphoma cells due to induction of oxidative stress by the Ag-NPs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.