ArticleNucleic acids research2012
QGRS-H Predictor: a web server for predicting homologous quadruplex forming G-rich sequence motifs in nucleotide sequences.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- RNA G‑Quadruplex Reprogramming with Guanine-Rich Antisense Oligonucleotides Inhibits Monoamine Oxidase B's Translation.ACS bio & med chem Au · 2025Article
- Assessing the impacts of various factors on circular RNA reliability.Life science alliance · 2023Article
- G4-Interacting DNA Helicases and Polymerases: Potential Therapeutic Targets.Current medicinal chemistry · 2019Review
- Identifying sequence features that drive ribosomal association for lncRNA.BMC genomics · 2018Article
- Article
- Motif independent identification of potential RNA G-quadruplexes by G4RNA screener.Bioinformatics (Oxford, England) · 2017Article
- PISMA: A Visual Representation of Motif Distribution in DNA Sequences.Bioinformatics and biology insights · 2017Article
- A G-Rich Motif in the lncRNA Braveheart Interacts with a Zinc-Finger Transcription Factor to Specify the Cardiovascular Lineage.Molecular cell · 2016Article
- QuadBase2: web server for multiplexed guanine quadruplex mining and visualization.Nucleic acids research · 2016Article
- Hidden genes in birds.Genome biology · 2015Article
- Exploring possible DNA structures in real-time polymerase kinetics using Pacific Biosciences sequencer data.BMC bioinformatics · 2015Article
- Article
- Isolation of single-stranded DNA aptamers that distinguish influenza virus hemagglutinin subtype H1 from H5.PloS one · 2015Article
- MOV10 and FMRP regulate AGO2 association with microRNA recognition elements.Cell reports · 2014Article
- Identification and characterization of RNA guanine-quadruplex binding proteins.Nucleic acids research · 2014Article
- QGRS-Conserve: a computational method for discovering evolutionarily conserved G-quadruplex motifs.Human genomics · 2014Article
- Article
- Bioinformatic analysis reveals an evolutional selection for DNA:RNA hybrid G-quadruplex structures as putative transcription regulatory elements in warm-blooded animals.Nucleic acids research · 2013Article
- Development of an undergraduate bioinformatics degree program at a liberal arts college.The Yale journal of biology and medicine · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Naturally occurring G-quadruplex structural motifs, formed by guanine-rich nucleic acids, have been reported in telomeric, promoter and transcribed regions of mammalian genomes. G-quadruplex structures have received significant attention because of growing evidence for their role in important biological processes, human disease and as therapeutic targets. Lately, there has been much interest in the potential roles of RNA G-quadruplexes as cis-regulatory elements of post-transcriptional gene expression. Large-scale computational genomics studies on G-quadruplexes have difficulty validating their predictions without laborious testing in 'wet' labs. We have developed a bioinformatics tool, QGRS-H Predictor that can map and analyze conserved putative Quadruplex forming 'G'-Rich Sequences (QGRS) in mRNAs, ncRNAs and other nucleotide sequences, e.g. promoter, telomeric and gene flanking regions. Identifying conserved regulatory motifs helps validate computations and enhances accuracy of predictions. The QGRS-H Predictor is particularly useful for mapping homologous G-quadruplex forming sequences as cis-regulatory elements in the context of 5'- and 3'-untranslated regions, and CDS sections of aligned mRNA sequences. QGRS-H Predictor features highly interactive graphic representation of the data. It is a unique and user-friendly application that provides many options for defining and studying G-quadruplexes. The QGRS-H Predictor can be freely accessed at: http://quadruplex.ramapo.edu/qgrs/app/start.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.