ArticleAge (Dordrecht, Netherlands)2013
Specific saccade deficits in patients with Alzheimer's disease at mild to moderate stage and in patients with amnestic mild cognitive impairment.
Article in Age (Dordrecht, Netherlands), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The application of saccades to assess cognitive impairment among older adults: a systematic review and meta-analysis.Aging clinical and experimental research · 2023Pooled it
- Saccadic Eye Movement in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review and Meta-Analysis.Neuropsychology review · 2022Pooled it
- Prosaccade and Antisaccade Paradigms in Persons with Alzheimer's Disease: A Meta-Analytic Review.Neuropsychology review · 2018Pooled it
- The Association between Saccadic Eye Movement Parameters and Mild Cognitive Impairment: The Nagahama Study.Ophthalmology science · 2026Article
- Utility of Tablet-Based Eye Tracking for Early Screening of Poststroke Cognitive Impairment: Diagnostic Cohort Study.JMIR mHealth and uHealth · 2026Article
- Application of Deep Multi-Scale Representation Learning Based on Eye-Tracking and Facial Expression Data in Cognitive Decline Assessment.Sensors (Basel, Switzerland) · 2026Article
- Simultaneous Analysis of Microsaccades and Pupil Size Variations in Age-Related Cognitive Impairment Using Eye-Tracking Technology.Journal of eye movement research · 2026Article
- A Comparative Analysis of Eye Movement Accuracy for Locating Items Held in Visual Short-Term Memory Among Young Healthy Adults, Older Adults With Normal Cognition, and Older Adults Indicative of Mild Cognitive Impairment.Brain and behavior · 2025Article
- Saccadic eye movements in neurological disease: cognitive mechanisms and clinical applications.Journal of neurology · 2025Review
- Quantifying Mild Cognitive Impairments in Older Adults Using Multi-modal Wearable Sensor Data in a Kitchen Environment.medRxiv : the preprint server for health sciences · 2025Article
- Eye Tracking as a Tool for Detecting Alzheimer's Disease in People With Down Syndrome.Journal of intellectual disability research : JIDR · 2025Article
- Can Saccade and Vergence Properties Discriminate Stroke Survivors from Individuals with Other Pathologies? A Machine Learning Approach.Brain sciences · 2025Article
- Eye tracking based clustering using the Korean version of the reading the mind in the eyes test.Scientific reports · 2025Article
- Interocular Timing Differences in Horizontal Saccades of Ball Game Players.Vision (Basel, Switzerland) · 2025Article
- The link between eye movements and cognitive function in mild to moderate Alzheimer's disease.Experimental brain research · 2025Article
- Eye movement abnormalities in Alzheimer's disease and other neurodegenerative dementias: insights from current evidence and priorities for future research.Frontiers in ophthalmology · 2025Review
- A detection model of cognitive impairment via the integrated gait and eye movement analysis from a large Chinese community cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Advancements in eye movement measurement technologies for assessing neurodegenerative diseases.Frontiers in digital health · 2024Review
- Research Progress of Eye Movement Analyses and its Detection Algorithms in Alzheimer's Disease.Current Alzheimer research · 2024Review
- Eye movements in patients with post-COVID condition.Biomedical optics express · 2023Article
Corrections and comments
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Saccadic impairment in Alzheimer's disease (AD) was found in horizontal saccades. The present study extends investigation to vertical saccades in a large number of subjects, including AD and amnestic mild cognitive impairment (aMCI). We examined both horizontal and vertical saccades in 30 healthy elderly, 18 aMCI, and 25 AD. Two tasks were used: gap (fixation target extinguishes prior to target onset) and overlap (fixation stays on after target onset). Eye movements were recorded with the Eyeseecam system. (1) Robust gap effect (shorter latencies in gap than in overlap) exists for AD and aMCI patients as for healthy elderly; (2) abnormal long latency of saccades in gap and overlap tasks for AD relative to healthy elderly and aMCI patients; (3) longer latency for aMCI patients than for healthy elderly for the overlap task; (4) significant correlation between scores of Mini-Mental State Examination (MMSE) and latencies of saccades considering the AD group only; (5) higher coefficient of variation in latency for AD patients than for healthy elderly and for aMCI patients; (6) variability of accuracy and speed is abnormally higher in AD patients than in aMCI and healthy elderly. Abnormalities of latency and latency-accuracy-speed variability reflect deficits of cerebral areas involved in the triggering and execution of saccades; latency of saccades can be used as follow-up test for aMCI and AD patients with its significant correlation with the changes of MMSE scores.
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