Cardiovascular biology: Escaped DNA inflames the heart.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

9 citing papers in PubMed.

1. Cell-free mitochondrial DNA as a pro-inflammatory agent in blood circulation: mechanisms, therapeutic implications, and clinical challenges in immune dysregulation.Frontiers in immunology · 2025
   Review
2. Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes.Cell biology and toxicology · 2023
   Article
3. Obesity-associated extracellular mtDNA activates central TGFβ pathway to cause blood pressure increase.American journal of physiology. Endocrinology and metabolism · 2017
   Article
4. Cell-free mitochondrial DNA in CSF is associated with early viral rebound, inflammation, and severity of neurocognitive deficits in HIV infection.Journal of neurovirology · 2016
   Article
5. Plasma nuclear and mitochondrial DNA levels in acute myocardial infarction patients.Coronary artery disease · 2015
   Article
6. Mitochondrially targeted Endonuclease III has a powerful anti-infarct effect in an in vivo rat model of myocardial ischemia/reperfusion.Basic research in cardiology · 2015
   Article
7. LOX-1, mtDNA damage, and NLRP3 inflammasome activation in macrophages: implications in atherogenesis.Cardiovascular research · 2014
   Article
8. Oxidant stress in mitochondrial DNA damage, autophagy and inflammation in atherosclerosis.Scientific reports · 2013
   Article
9. Danger signals in the initiation of the inflammatory response after myocardial infarction.Mediators of inflammation · 2013
   Review

Corrections and comments

• Comment on
  Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure.2012

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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