ArticleDevelopmental biology2012
raw Functions through JNK signaling and cadherin-based adhesion to regulate Drosophila gonad morphogenesis.
Article in Developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Nerve injury promotes glial immune responses through a Draper/Ninjurin A pathway.Neurobiology of disease · 2026Article
- Article
- Opposing roles of Fos, Raw, and SARM1 in the regulation of axonal degeneration and synaptic structure.Frontiers in cellular neuroscience · 2023Article
- Modulation of Global Gene Expression by Aneuploidy and CNV of Dosage Sensitive Regulatory Genes.Genes · 2021Article
- Cell-to-cell communication mediates glioblastoma progression inBiology open · 2020Article
- Glioblastoma cells vampirize WNT from neurons and trigger a JNK/MMP signaling loop that enhances glioblastoma progression and neurodegeneration.PLoS biology · 2019Article
- Article
- Degeneration of Injured Axons and Dendrites Requires Restraint of a Protective JNK Signaling Pathway by the Transmembrane Protein Raw.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- An RNAi Screen Identifies New Genes Required for Normal Morphogenesis of Larval Chordotonal Organs.G3 (Bethesda, Md.) · 2018Article
- Identification of raw as a regulator of glial development.PloS one · 2018Article
- ATF3 acts as a rheostat to control JNK signalling during intestinal regeneration.Nature communications · 2017Article
- Regulation of Gonad Morphogenesis in Drosophila melanogaster by BTB Family Transcription Factors.PloS one · 2016Article
- Loss of Cell Adhesion Increases Tumorigenic Potential of Polarity Deficient Scribble Mutant Cells.PloS one · 2016Article
- Host genetic determinants of microbiota-dependent nutrition revealed by genome-wide analysis of Drosophila melanogaster.Nature communications · 2015Article
- Coordinate control of terminal dendrite patterning and dynamics by the membrane protein Raw.Development (Cambridge, England) · 2015Article
- acal is a long non-coding RNA in JNK signaling in epithelial shape changes during drosophila dorsal closure.PLoS genetics · 2015Article
- Sonication-facilitated immunofluorescence staining of late-stage embryonic and larval Drosophila tissues in situ.Journal of visualized experiments : JoVE · 2014Article
- Lsd1 restricts the number of germline stem cells by regulating multiple targets in escort cells.PLoS genetics · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
To form a gonad, germ cells (GCs) and somatic gonadal precursor cells (SGPs) must migrate to the correct location in the developing embryo and establish the cell-cell interactions necessary to create proper gonad architecture. During gonad morphogenesis, SGPs send out cellular extensions to ensheath the individual GCs and promote their development. We have identified mutations in the raw gene that result in a failure of the SGPs to ensheath the GCs, leading to defects in GC development. Using genetic analysis and gene expression studies, we find that Raw negatively regulates JNK signaling during gonad morphogenesis, and increased JNK signaling is sufficient to cause ensheathment defects. In particular, Raw functions upstream of the Drosophila Jun-related transcription factor to regulate its subcellular localization. Since JNK signaling regulates cell adhesion during the morphogenesis of many tissues, we examined the relationship between raw and the genes encoding Drosophila E-cadherin and β-catenin, which function together in cell adhesion. We find that loss of DE-cadherin strongly enhances the raw mutant gonad phenotype, while increasing DE-cadherin function rescues this phenotype. Further, loss of raw results in mislocalization of β-catenin away from the cell surface. Therefore, cadherin-based cell adhesion, likely at the level of β-catenin, is a primary mechanism by which Raw regulates germline-soma interaction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.