Evidence map›Paper›PMID 2257521›Full record

ArticleCalcified tissue international1990

Diurnal rhythm and 24-hour integrated concentrations of serum osteocalcin in normals: influence of age, sex, season, and smoking habits.

H K Nielsen, K Brixen, L Mosekilde

Abstract read
PubMed Publisher
In one paragraph

Article in Calcified tissue international, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. The utility of dried blood spot measurement of bone turnover markers in biological anthropology.American journal of human biology : the official journal of the Human Biology Council · 2022
    Pooled it
  2. Pooled it
  3. Effect of Ramadan fasting in Saudi Arabia on serum bone profile and immunoglobulins.Therapeutic advances in endocrinology and metabolism · 2015
    Article
  4. Article
  5. Vitamin d deficiency in cystic fibrosis.International journal of endocrinology · 2010
    Article
  6. Reference database of biochemical markers of bone turnover for the Japanese female population. Japanese Population-based Osteoporosis (JPOS) Study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2004
    Article
  7. Circadian rhythm in type I collagen formation in postmenopausal women with and without osteopenia.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 1995
    Article
  8. Risk of osteoporosis in men with chronic bronchitis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 1992
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

H K NielsenUniversity Department of Endocrinology and Metabolism, Aarhus Count Hospital, Denmark.
K Brixen
L Mosekilde

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present study we examined whether the diurnal pattern and the 24-hour integrated serum concentration of osteocalcin (S-OC(I] showed any variation due to age, sex, season, or smoking habits in 31 normal subjects, aged 23-47 years. Blood samples were drawn every 60 minutes from 4 p.m. until 6 p.m. the following day. Serum osteocalcin showed diurnal variation as described earlier but no influence of age or sex on the diurnal variation could be demonstrated. Ten subjects were smokers, all consuming more than 10 cigarettes daily, but the diurnal variation in OC with time was not different from an age-, sex-, and height-matched group of strictly nonsmokers. Sixteen of the subjects were initially examined in March and 15 in November. Eight subjects were examined during a period in both November and March, and 5 of these went through an additional study period in July. These seasonal studies showed that the diurnal time course pattern during different seasons of the year were statistically indistinguishable from each other. The S-OC(I) was significantly higher in subjects below 29 years of age compared with subjects aged 30-40 years (P less than 0.01). Men had higher values than women (P less than 0.05). Moreover, S-OC(I) was higher in November compared to March (P less than 0.05). There was no effect of smoking on S-OC(I). A significant correlation existed between S-OC(I) and age (r = 0.50, P less than 0.005). Multiple regression showed that among age, height, and weight, only age and height were significant determinants for S-OC(I) (r = 0.50, P = 0.02).(ABSTRACT TRUNCATED AT 250 WORDS)

Indexed as

AdultAge FactorsCircadian RhythmFemaleHumansMaleMiddle AgedOsteocalcinSeasonsSex FactorsSmokingOsteocalcin

Identifiers

PMID2257521

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.