ArticlePreventing chronic disease2012
In search of a germ theory equivalent for chronic disease.
Article in Preventing chronic disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Dietary Polyphenols-Important Non-Nutrients in the Prevention of Chronic Noncommunicable Diseases. A Systematic Review.Nutrients · 2019Pooled it
- Whole grain diet reduces systemic inflammation: A meta-analysis of 9 randomized trials.Medicine · 2018Pooled it
- Dairy foods and dairy proteins in the management of type 2 diabetes: a systematic review of the clinical evidence.Advances in nutrition (Bethesda, Md.) · 2015Pooled it
- Substituting whole grains for refined grains in a 6-wk randomized trial has a modest effect on gut microbiota and immune and inflammatory markers of healthy adults.The American journal of clinical nutrition · 2017Trial
- Endogenous Hypersensitivity Infection: A Unifying Framework forMicroorganisms · 2026Review
- Review of evidence linking exposure to environmental stressors and associated alterations in the dynamics of immunosenescence (ISC) with the global increase in multiple sclerosis (MS).Immunity & ageing : I & A · 2024Review
- Adhesive Capsulitis of the Ankle (Frozen Ankle): An Infrequent Syndrome.Biomedicines · 2023Review
- Potential anti neuro-inflammatory effect of BioCen-128 in animal models of dementia.Animal models and experimental medicine · 2022Article
- Exploring the Links Between Biophilic and Restorative Qualities of Exterior and Interior Spaces in Leon, Guanajuato, Mexico.Frontiers in psychology · 2021Article
- A Comprehensive View of Frozen Shoulder: A Mystery Syndrome.Frontiers in medicine · 2021Review
- Urbanization and health: The effects of the built environment on chronic disease risk factors among women in Tanzania.PloS one · 2020Article
- The multifaceted link between inflammation and human diseases.Journal of cellular physiology · 2018Review
- Diet Composition for the Management of Obesity and Obesity-related Disorders.Journal of diabetes mellitus and metabolic syndrome · 2018Article
- On the analysis of complex biological supply chains: From Process Systems Engineering to Quantitative Systems Pharmacology.Computers & chemical engineering · 2017Article
- Nutritional approaches for managing obesity-associated metabolic diseases.The Journal of endocrinology · 2017Review
- Composite Hydrogels with Engineered Microdomains for Optical Glucose Sensing at Low Oxygen Conditions.Biosensors · 2017Article
- The Built Environment-A Missing "Cause of the Causes" of Non-Communicable Diseases.International journal of environmental research and public health · 2016Article
- Quantitative Systems Pharmacology: A Framework for Context.Current pharmacology reports · 2016Article
- Influence of a 10-Day Mimic of Our Ancient Lifestyle on Anthropometrics and Parameters of Metabolism and Inflammation: The "Study of Origin".BioMed research international · 2016Article
- Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes.Cell metabolism · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fight against infectious disease advanced dramatically with the consolidation of the germ theory in the 19th century. This focus on a predominant cause of infections (ie, microbial pathogens) ultimately led to medical and public health advances (eg, immunization, pasteurization, antibiotics). However, the resulting declines in infections in the 20th century were matched by a rise in chronic, noncommunicable diseases, for which there is no single underlying etiology. The discovery of a form of low-grade systemic and chronic inflammation ("metaflammation"), linked to inducers (broadly termed "anthropogens") associated with modern man-made environments and lifestyles, suggests an underlying basis for chronic disease that could provide a 21st-century equivalent of the germ theory.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.