Evidence map›Paper›PMID 22574861›Full record

SynthesisAddiction biology2013

Functional neuroimaging studies of alcohol cue reactivity: a quantitative meta-analysis and systematic review.

Joseph P Schacht, Raymond F Anton, Hugh Myrick

3 registry-linked trialsOpen access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Addiction biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 299 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
299citing papers in PubMed, 10 pooled it
13.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03220776 phase2completednot on this mapstarted 2017, after this paper: background citation

Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics

TypeinterventionalSponsorMedical University of South CarolinaRan2017 to 2022Enrolled54ConditionsAlcohol Use Disorder, Bipolar DisorderArmsN-Acetylcysteine, Gabapentin, Placebo Oral Tablet
NCT03842670 nacompletednot on this mapstarted 2018, after this paper: background citation

Neurocognitive and Neurobehavioral Mechanisms of Change Following Psychological

TypeinterventionalSponsorUniversity of New MexicoRan2018 to 2025Enrolled110ConditionsAlcohol Use Disorder, Alcohol Abuse, Alcohol Drinking, Alcohol DependenceArmsCognitive Behavior Therapy, Mindfulness Based Relapse Prevention
NCT04106739 nacompletednot on this mapstarted 2019, after this paper: background citation

Auricular Percutaneous Electrical Neural Field Stimulation in Short-Term Treatment of Alcohol Dependence- Neurohaemodynamic Correlates and Feasibility Study

TypeinterventionalSponsorDyAnsys, Inc.Ran2019 to 2021Enrolled44ConditionsAlcohol Use DisorderArmsDrug Relief V(version) 2.0 Auricular Percutaneous Electrical Neural Field Stimulation (PENFS)
3 · Its place in the literature

Who cites it

299 citing papers in PubMed, 10 syntheses or guidelines pooled it, 589 citations in OpenAlex.

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  15. The neural and psychophysiological effects of cannabidiol in youth with alcohol use disorder: A randomized controlled clinical trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
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239 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Joseph P SchachtCenter for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, 29425, USA. schacht@musc.edu
Raymond F Anton
Hugh Myrick
Medical University of South Carolina · USRalph H. Johnson VA Medical Center · US

Funding

TREATING ETHANOL WITHDRAWAL WITH LORAZEPAM/NALTREXONEP50AA010761 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Patrick J. Mulholland · 1996 to 2026
$46.8M
TRAINING IN ALCOHOL TREATMENT RESEARCHT32AA007474 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI John J. Woodward · 1987 to 2026
$8.5M
Genetic and brain mechanisms of naltrexone's treatment efficacy for alcoholismR01AA017633 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ANTON, RAYMOND F · 2009 to 2014
$2.6M
Career Development and Mentoring in Clinical/Translational Alcohol ResearchK05AA017435 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ANTON, RAYMOND F · 2008 to 2017
$2.2M
NIAAA NIH HHS K05 AA017435NIAAA NIH HHS P50 AA010761NIAAA NIH HHS R01 AA017633NIAAA NIH HHS T32 AA007474
6 · The paper itself

Abstract

A comprehensive understanding of the neurobiology of alcohol cue reactivity is critical in identifying the neuropathology of alcohol use disorders (AUD) and developing treatments that may attenuate alcohol craving and reduce relapse risk. Functional neuroimaging studies have identified many brain areas in which alcohol cues elicit activation. However, extant studies have included relatively small numbers of cases, with AUD of varying severity, and have employed many different cue paradigms. We used activation likelihood estimation, a quantitative, coordinate-based meta-analytic method, to analyze the brain areas activated by alcohol-related cues across studies, and to examine whether these areas were differentially activated between cases and controls. Secondarily, we reviewed correlations between behavioral measures and cue-elicited activation, as well as treatment effects on such activation. Data analyzed were from 28 studies of 679 cases and 174 controls. Among cases, alcohol cues elicited robust activation of limbic and prefrontal regions, including ventral striatum, anterior cingulate and ventromedial prefrontal cortex. As compared to controls, cases demonstrated greater activation of parietal and temporal regions, including posterior cingulate, precuneus and superior temporal gyrus. Cue-elicited activation of ventral striatum was most frequently correlated with behavioral measures and most frequently reduced by treatment, but these results were often derived from region-of-interest analyses that interrogated only limbic regions. These findings support long-standing theories of mesolimbic involvement in alcohol cue processing, but suggest that cue-elicited activation of other brain areas may more clearly differentiate cases from controls. Prevention and treatment for AUD should consider interventions that may reduce cue-elicited activation of these areas.

Indexed as

CuesFunctional NeuroimagingAlcohol-Related DisordersBasal GangliaBehavior, AddictiveBrainCase-Control StudiesData Interpretation, StatisticalEthanolGyrus CinguliHumansMagnetic Resonance ImagingPositron-Emission TomographyPrefrontal CortexTomography, Emission-Computed, Single-PhotonEthanol

Identifiers

PMID22574861
PMCPMC3419322
OpenAlexW1551563638

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.