Evidence map›Paper›PMID 22574264›Full record

ArticleBiomedical optics express2012

Seeing it through: translational validation of new medical imaging modalities.

Melissa B Aldrich, Milton V Marshall, Eva M Sevick-Muraca, Greg Lanza, John Kotyk, Joseph Culver, Lihong V Wang, Jashim Uddin, Brenda C Crews, Lawrence J Marnett and 9 more

Abstract read
In one paragraph

Article in Biomedical optics express, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Melissa B Aldrich
Milton V Marshall
Eva M Sevick-Muraca
Greg Lanza
John Kotyk
Joseph Culver
Lihong V Wang
Jashim Uddin
Brenda C Crews
Lawrence J Marnett
Joseph C Liao
Chris Contag
James M Crawford
Ken Wang
Bill Reisdorph
Henry Appelman
D Kim Turgeon
Charles Meyer
Tom Wang

Funding

Task Specific Project 3: Diffuse Optical TomographyU54CA136398 · NCI · WASHINGTON UNIVERSITY · PI WANG, LIHONG · 2008 to 2012
$6.0M
Task Specific Project 4U54CA136429 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI REHEMTULLA, ALNAWAZ · 2008 to 2012
$5.2M
Targeted Multi-Spectral Dual Axes Confocal Imaging of In Vivo Molecular ExpressioR01CA142750 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KURABAYASHI, KATSUO, LUKER, GARY D · 2010 to 2014
$2.4M
HIGH-SENSITIVITY DOT FOR MAPPING HUMAN BRAIN FUNCTIONR01EB009233 · NIBIB · WASHINGTON UNIVERSITY · PI CULVER, JOSEPH P · 2009 to 2012
$1.6M
NCI NIH HHS R01 CA142750NCI NIH HHS U54 CA136398NCI NIH HHS U54 CA136429NIBIB NIH HHS R01 EB009233
6 · The paper itself

Abstract

Medical imaging is an invaluable tool for diagnosis, surgical guidance, and assessment of treatment efficacy. The Network for Translational Research (NTR) for Optical Imaging consists of four research groups working to "bridge the gap" between lab discovery and clinical use of fluorescence- and photoacoustic-based imaging devices used with imaging biomarkers. While the groups are using different modalities, all the groups face similar challenges when attempting to validate these systems for FDA approval and, ultimately, clinical use. Validation steps taken, as well as future needs, are described here. The group hopes to provide translational validation guidance for itself, as well as other researchers.

Indexed as

(170.0110) Imaging systems(170.3880) Medical and biological imaging

Identifiers

PMID22574264
PMCPMC3345805

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.