ArticlePloS one2012
Noradrenergic control of gene expression and long-term neuronal adaptation evoked by learned vocalizations in songbirds.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Auditory Representation of Vocal Signals in a Pallial Cortical Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Tutor auditory memory for guiding sensorimotor learning in birdsong.Frontiers in neural circuits · 2024Review
- Neural circuit for social authentication in song learning.Nature communications · 2022Article
- Locus Coeruleus in Non-Mammalian Vertebrates.Brain sciences · 2022Review
- A high sensitivity ZENK monoclonal antibody to map neuronal activity in Aves.Scientific reports · 2020Article
- Implicit Memory for Complex Sounds in Higher Auditory Cortex of the Ferret.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Neuroestrogens rapidly shape auditory circuits to support communication learning and perception: Evidence from songbirds.Hormones and behavior · 2018Review
- Sound-induced monoaminergic turnover in the auditory forebrain depends on endocrine state in a seasonally-breeding songbird.Journal of neuroendocrinology · 2018Article
- Norepinephrine enhances song responsiveness and encoding in the auditory forebrain of male zebra finches.Journal of neurophysiology · 2018Article
- Neuromodulation and a Reconceptualization of Autism Spectrum Disorders: Using the Locus Coeruleus Functioning as an Exemplar.Frontiers in neurology · 2018Article
- Article
- Topography and Lateralized Effect of Acute Aromatase Inhibition on Auditory Processing in a Seasonal Songbird.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Serotonin, estrus, and social context influence c-Fos immunoreactivity in the inferior colliculus.Behavioral neuroscience · 2016Article
- Auditory experience-dependent cortical circuit shaping for memory formation in bird song learning.Nature communications · 2016Article
- Mechanisms underlying the social enhancement of vocal learning in songbirds.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Socially induced serotonergic fluctuations in the male auditory midbrain correlate with female behavior during courtship.Journal of neurophysiology · 2016Article
- Norepinephrine Modulates Coding of Complex Vocalizations in the Songbird Auditory Cortex Independent of Local Neuroestrogen Synthesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The opportunities and challenges of large-scale molecular approaches to songbird neurobiology.Neuroscience and biobehavioral reviews · 2015Review
- Catecholaminergic connectivity to the inner ear, central auditory, and vocal motor circuitry in the plainfin midshipman fish porichthys notatus.The Journal of comparative neurology · 2014Article
- Development of neural responsivity to vocal sounds in higher level auditory cortex of songbirds.Journal of neurophysiology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Norepinephrine (NE) is thought to play important roles in the consolidation and retrieval of long-term memories, but its role in the processing and memorization of complex acoustic signals used for vocal communication has yet to be determined. We have used a combination of gene expression analysis, electrophysiological recordings and pharmacological manipulations in zebra finches to examine the role of noradrenergic transmission in the brain's response to birdsong, a learned vocal behavior that shares important features with human speech. We show that noradrenergic transmission is required for both the expression of activity-dependent genes and the long-term maintenance of stimulus-specific electrophysiological adaptation that are induced in central auditory neurons by stimulation with birdsong. Specifically, we show that the caudomedial nidopallium (NCM), an area directly involved in the auditory processing and memorization of birdsong, receives strong noradrenergic innervation. Song-responsive neurons in this area express α-adrenergic receptors and are in close proximity to noradrenergic terminals. We further show that local α-adrenergic antagonism interferes with song-induced gene expression, without affecting spontaneous or evoked electrophysiological activity, thus dissociating the molecular and electrophysiological responses to song. Moreover, α-adrenergic antagonism disrupts the maintenance but not the acquisition of the adapted physiological state. We suggest that the noradrenergic system regulates long-term changes in song-responsive neurons by modulating the gene expression response that is associated with the electrophysiological activation triggered by song. We also suggest that this mechanism may be an important contributor to long-term auditory memories of learned vocalizations.
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