ArticleJournal of clinical biochemistry and nutrition2012
Lowering homocysteine and modifying nutritional status with folic acid and vitamin B(12) in Indian patients of vascular disease.
Article in Journal of clinical biochemistry and nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Prevalence of hyperhomocysteinemia in South Asian patients with heart disease: a systematic review and meta-analysis.BMC cardiovascular disorders · 2026Pooled it
- Association between low-dose folic acid supplementation and blood lipids concentrations in male and female subjects with atherosclerosis risk factors.Medical science monitor : international medical journal of experimental and clinical research · 2013Trial
- Article
- Homocysteine and nutritional biomarkers in cognitive impairment.Molecular and cellular biochemistry · 2023Article
- Prevalence and predictors of low folate levels among stroke survivors in a country without mandatory folate food fortification: Analysis of a Ghanaian sample.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2023Article
- Micronutrient Deficiencies and Anemia in Urban India-Do We Need Food Fortification?Indian journal of clinical biochemistry : IJCB · 2022Article
- Folate Status and Mortality in US Adults With Diabetes: A Nationally Representative Cohort Study.Frontiers in cardiovascular medicine · 2022Article
- Review
- Role of Homocysteine in Cognitive Impairement and Alzheimer's Disease.Indian journal of clinical biochemistry : IJCB · 2018Review
- Nutritional status and coronary artery disease: a cross sectional study.Iranian Red Crescent medical journal · 2014Article
- Nutriepigenetic regulation by folate-homocysteine-methionine axis: a review.Molecular and cellular biochemistry · 2014Review
- Prevalence of hyperhomocysteinemia in healthy Indian doctors.Bioinformation · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperhomocysteinemia is more commonly associated with vascular disease in Indians than in the western populations. It is caused by genetic polymorphisms or dietary deficiencies of the B vitamins. We attempted to identify the association of hyperhomocysteinemia with vitamin B(12) and folate in Indian patients of vascular disease. Homocysteine, vitamin B(12) and folate levels were estimated in 100 controls and 100 patients of vascular disease. Homocysteine estimation was repeated in 73 patients on different vitamin supplements for 6 months. Homocysteine exhibited a significant negative correlation with B(12) only in cerebrovascular disease and peripheral vascular diseasepatients, and with folate in coronary artery disease and cerebrovascular disease patients as well as controls. Single daily dose of folate was as effective as a combination of folate and cobalamin in reducing plasma homocysteine concentrations. Low levels of B(12) contribute to the higher incidence of cerebrovascular disease and peripheral vascular disease, and low folate levels account for higher prevalence of hyperhomocysteinemia in coronary artery disease and cerebrovascular disease. Moreover, irrespective of the cause of hyperhomocysteinemia, folate is known to ameliorate it. Hence, large-scale corrective measures like food fortification or dietary supplementation with folate might benefit the Indian population and reduce the incidence and morbidity of vascular disease.
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