ArticleJournal of virology2012
Colonial history and contemporary transmission shape the genetic diversity of hepatitis C virus genotype 2 in Amsterdam.
Article in Journal of virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Unravelling HCV diversity and resistance in Viet Nam: a cross-sectional analysis.The Lancet regional health. Western Pacific · 2026Article
- Review
- HCV-HIV Chronic Coinfection Prevalence in Amazon Region.Journal of clinical medicine · 2022Article
- Association of hepatitis C virus genotype 2 spread with historic slave trade and commerce routes in Western Africa.Virus evolution · 2022Article
- Time and Mode of Epidemic HCV-2 Subtypes Spreading in Europe: Phylodynamics in Italy and Albania.Diagnostics (Basel, Switzerland) · 2021Article
- Direct-Acting Antiviral Treatment for Hepatitis C Genotypes Uncommon in High-Income Countries: A Dutch Nationwide Cohort Study.Open forum infectious diseases · 2021Article
- Article
- Article
- The changing epidemiology of primary liver cancer.Current epidemiology reports · 2019Article
- Aspects on the history of transmission and favor of distribution of viruses by iatrogenic action: perhaps an example of a paradigm of the worldwide spread of HIV.Medical microbiology and immunology · 2017Review
- Accurate quantification of within- and between-host HBV evolutionary rates requires explicit transmission chain modelling.Virus evolution · 2017Article
- The epidemic dynamics of hepatitis C virus subtypes 4a and 4d in Saudi Arabia.Scientific reports · 2017Article
- Genetic diversity of hepatitis C virus in Ethiopia.PloS one · 2017Article
- Geographic integration of hepatitis C virus: A global threat.World journal of virology · 2016Article
- Global epidemiology of hepatitis C virus infection: An up-date of the distribution and circulation of hepatitis C virus genotypes.World journal of gastroenterology · 2016Review
- Phylogenetic Analysis and Epidemic History of Hepatitis C Virus Genotype 2 in Tunisia, North Africa.PloS one · 2016Article
- Evolutionary and Phylogenetic Analysis of the Hepaciviruses and Pegiviruses.Genome biology and evolution · 2015Article
- Risk Factors for Sexual Transmission of Hepatitis C Virus Among Human Immunodeficiency Virus-Infected Men Who Have Sex With Men: A Case-Control Study.Open forum infectious diseases · 2015Article
- The full-length genome sequences of nine HCV genotype 4 variants representing a new subtype 4s and eight unclassified lineages.Virology · 2015Article
- Global distribution and prevalence of hepatitis C virus genotypes.Hepatology (Baltimore, Md.) · 2015Article
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Authors and funding
9 authors.
Funding
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Abstract
Evolutionary analysis of hepatitis C virus (HCV) genome sequences has provided insights into the epidemic history and transmission of this widespread human pathogen. Here we report an exceptionally diverse set of 178 HCV genotype 2 (HCV-2) isolates from 189 patients in Amsterdam, comprising 8 distinct HCV subtypes and 10 previously not recognized, unclassified lineages. By combining study subjects' demographic information with phylogeographic and molecular clock analyses, we demonstrate for the first time that the trans-Atlantic slave trade and colonial history were the driving forces behind the global dissemination of HCV-2. We detect multiple HCV-2 movements from present-day Ghana/Benin to the Caribbean during the peak years of the slave trade (1700 to 1850) and extensive transfer of HCV-2 among the Netherlands and its former colonies Indonesia and Surinam over the last 150 years. The latter coincides with the bidirectional migration of Javanese workers between Indonesia and Surinam and subsequent immigration to the Netherlands. In addition, our study sheds light on contemporary trends in HCV transmission within the Netherlands. We observe multiple lineages of the epidemic subtypes 2a, 2b, and 2c (together 67% of HCV-2 infections in Amsterdam), which cluster according to their suspected routes of transmission, specifically, injecting drug use (IDU) and contaminated blood/blood products. Understanding the epidemiological processes that generated the global pattern of HCV diversity seen today is critical for exposing associations between populations, risk factors, and specific HCV subtypes and might help HCV screening and prevention campaigns to minimize the future burden of HCV-related liver disease.
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