ArticlePalliative medicine2013
Patient perspectives on participation in the ENABLE II randomized controlled trial of a concurrent oncology palliative care intervention: benefits and burdens.
Article in Palliative medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06044441 (ENABLE-SG), which is not on this map. Cited by 36 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ENABLE-SG (Educate, Nurture, Advise, Before Life Ends for Singapore) as a Proactive Palliative Care Model: Evaluation and Implementation Preparation
Who cites it
36 citing papers in PubMed, 5 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- The effectiveness and cost-effectiveness of hospital-based specialist palliative care for adults with advanced illness and their caregivers.The Cochrane database of systematic reviews · 2020Pooled it
- Integrated outpatient palliative care for patients with advanced cancer: A systematic review and meta-analysis.Palliative medicine · 2019Pooled it
- Patient empowerment, what does it mean for adults in the advanced stages of a life-limiting illness: A systematic review using critical interpretive synthesis.Palliative medicine · 2018Pooled it
- Multicomponent Palliative Care Interventions in Advanced Chronic Diseases: A Systematic Review.The American journal of hospice & palliative care · 2018Pooled it
- Early palliative care for adults with advanced cancer.The Cochrane database of systematic reviews · 2017Pooled it
- Trial
- Interaction effect of comorbid depression and proactive positivity coping strategy on the 1-year survival of patients with advanced cancer: a nationwide multicentre study in South Korea.BMC psychiatry · 2025Trial
- Burden of cancer trial participation: A qualitative sub-study of the INTERIM feasibility RCT.Chronic illness · 2023Trial
- Measuring positive psychosocial sequelae in patients with advanced cancer.Psychological trauma : theory, research, practice and policy · 2021Trial
- Benefits of Early Versus Delayed Palliative Care to Informal Family Caregivers of Patients With Advanced Cancer: Outcomes From the ENABLE III Randomized Controlled Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2015Trial
- Early Versus Delayed Initiation of Concurrent Palliative Oncology Care: Patient Outcomes in the ENABLE III Randomized Controlled Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2015Trial
- Timely integration of palliative care into oncology care for patients with bone metastases at the radiotherapy department: A pilot study on acceptability and feasibility.Technical innovations & patient support in radiation oncology · 2025Article
- ENABLE-SG (Educate, Nurture, Advise, Before Life Ends for Singapore) as a proactive palliative care model: protocol for a hybrid type 1 effectiveness-implementation randomized wait-list controlled trial.BMC palliative care · 2024Article
- Living fully, choosing wisely: Exploring patient-centred approaches to palliative care and MAiD - Part I.Canadian oncology nursing journal = Revue canadienne de nursing oncologique · 2024Article
- Stigma of Palliative Care among Patients with Advanced Cancer and Their Caregivers on Early Palliative Care.Cancers · 2023Article
- Article
- Research participation in palliative medicine-benefits and barriers for patients and families: rapid review and thematic synthesis.BMJ supportive & palliative care · 2023Review
- Patient & Caregiver Experiences: Qualitative Study Comparison Before and After Implementation of Early Palliative Care for Advanced Colorectal Cancer.The Canadian journal of nursing research = Revue canadienne de recherche en sciences infirmieres · 2023Article
- Perceptions of Death Among Patients with Advanced Cancer Receiving Early Palliative Care and Their Caregivers: Results from a Mixed-Method Analysis.The oncologist · 2023Article
- Doing palliative care research on hematologic cancer patients: A realist synthesis of literature and experts' opinion on what works, for whom and in what circumstances.Frontiers in oncology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundENABLE (Educate, Nurture, Advise Before Life Ends) II was one of the first randomized controlled trials (RCTs) examining the effects of a concurrent oncology palliative care intervention on quality of life, mood, and symptom control for advanced cancer patients and their caregivers. However, little is known about how participants experience early palliative care and the benefits and burdens of participating in a palliative care clinical trial.
aimTo gain a deeper understanding of participants' perspectives of the intervention and palliative care trial participation.
designA qualitative descriptive study using thematic analysis to determine benefits and burdens of a new palliative care intervention and trial participation. SETTING/
participantsOf the 72 participants who were alive when the study commenced, 53 agreed to complete an in-depth, semi-structured interview regarding the ENABLE II intervention and clinical trial participation.
resultsParticipants' perceptions of intervention benefits were represented by four themes: enhanced problem-solving skills, better coping, feeling empowered, and feeling supported or reassured. Three themes related to trial participation: helping future patients and contributing to science, gaining insight through completion of questionnaires, and trial/intervention aspects to improve.
conclusionsThe benefits of the intervention and the positive aspects of trial participation outweighed trial "burdens". This study raises additional important questions relevant to future trial design and intervention development: when should a palliative care intervention be initiated and what aspects of self-care and healthy living should be offered in addition to palliative content for advanced cancer patients when they are feeling well?
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.