ReviewWorld journal of pediatrics : WJP2012
Umbilical blood biomarkers for predicting early-onset neonatal sepsis.
Review in World journal of pediatrics : WJP, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Reliability of Interleukin-6 Alone and in Combination for Diagnosis of Early Onset Neonatal Sepsis: Systematic Review.Frontiers in pediatrics · 2022Pooled it
- Diagnosis value of the serum amyloid A test in neonatal sepsis: a meta-analysis.BioMed research international · 2013Pooled it
- Prolonged premature rupture of membranes with increased risk of infection is associated with gut accumulation ofComputational and structural biotechnology journal · 2024Article
- Cord blood presepsin as a predictor of early-onset neonatal sepsis in term and preterm newborns.Italian journal of pediatrics · 2023Article
- Identification and verification of feature biomarkers associated with immune cells in neonatal sepsis.European journal of medical research · 2023Article
- Ontogeny of plasma cytokine and chemokine concentrations across the first week of human life.Cytokine · 2021Article
- Interleukin-6 elevation in healthy neonates.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Article
- Cord Blood Haptoglobin, Cerebral Palsy and Death in Infants of Women at Risk for Preterm Birth: A Secondary Analysis of a Randomised Controlled Trial.EClinicalMedicine · 2019Article
- Cord blood neutropenia is an independent predictor of early sepsis.Journal of perinatology : official journal of the California Perinatal Association · 2017Observational
- Evaluation and Management of Women and Newborns With a Maternal Diagnosis of Chorioamnionitis: Summary of a Workshop.Obstetrics and gynecology · 2016Article
- Clinical chorioamnionitis at term VI: acute chorioamnionitis and funisitis according to the presence or absence of microorganisms and inflammation in the amniotic cavity.Journal of perinatal medicine · 2016Article
- Abandon the mouse research ship? Not just yet!Shock (Augusta, Ga.) · 2014Article
- Neonatal physiological correlates of near-term brain development on MRI and DTI in very-low-birth-weight preterm infants.NeuroImage. Clinical · 2014Article
- Neonatal sepsis and inflammatory mediators.Mediators of inflammation · 2014Review
- Article
- Flow cytometry in the detection of neonatal sepsis.International journal of pediatrics · 2013Article
- Umbilical cord blood IL-6 as predictor of early-onset neonatal sepsis in women with preterm prelabour rupture of membranes.PloS one · 2013Article
- Use of non-conventional biomarkers in the early diagnosis of acute kidney injury in preterm newborns with sepsis.Jornal brasileiro de nefrologiaReview
- Utility of cytokine, adhesion molecule and acute phase proteins in early diagnosis of neonatal sepsis.Journal of natural science, biology, and medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSince the 1990s, finding the most efficient markers or combinations as predictors of early-onset neonatal sepsis has been the hot topic of studies. But there is no review of such biomarkers detected in umbilical blood at birth. By comparing clinical values of common inflammatory markers detected in cord blood shortly after birth, in this study we tried to find the most performing one or the most efficient combination that might be potentially used in birth room, as the earliest predictor of early-onset neonatal sepsis. DATA SOURCES: We searched PubMed and Elsevier's Web of Science for studies evaluating cord blood inflammatory markers in relation to early-onset neonatal sepsis.
resultsAmong C-reactive protein (CRP), procalcitonin (PCT), IL-6, IL-8, TNF-α and IL-1β, none of them could be used individually to establish or exclude the diagnosis of early-onset neonatal sepsis, but PCT, IL-6 and IL-8 have great superiority to CRP, TNF-α and IL-1β. When combined with other hematological markers and clinical observation, the clinical reliability of PCT, IL-6 and IL-8 could be improved. Prolonging the sample collection time window seems to have a positive effect on the clinical utility of IL-6 and IL-8.
conclusionsMore researches focusing on the combination of different umbilical cord biomarkers in different clinical settings are needed to achieve clearer conclusions. Multi-center, large-sized analysis, especially examining groups of cytokines, is also expected.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.