ReviewJournal of mammary gland biology and neoplasia2012
Constructing three-dimensional models to study mammary gland branching morphogenesis and functional differentiation.
Review in Journal of mammary gland biology and neoplasia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed.
- Th1 Cytokines Inhibit Acinar Morphogenesis and Milk Protein Expression in 3D Mammary Cultures.Biomedicines · 2025Article
- Clinical applications of 3D normal and breast cancer organoids: A review of concepts and methods.Experimental biology and medicine (Maywood, N.J.) · 2022Review
- Simvastatin treatment varies the radiation response of human breast cells in 2D or 3D culture.Investigational new drugs · 2021Article
- Characterization of Organoid Cultures to Study the Effects of Pregnancy Hormones on the Epigenome and Transcriptional Output of Mammary Epithelial Cells.Journal of mammary gland biology and neoplasia · 2020Review
- The not-so-sweet side of sugar: Influence of the microenvironment on the processes that unleash cancer.Biochimica et biophysica acta. Molecular basis of disease · 2020Review
- AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network.Nature communications · 2020Article
- Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages.Nature communications · 2020Article
- Pre-aggregation of scalp progenitor dermal and epidermal stem cells activates the WNT pathway and promotes hair follicle formation in in vitro and in vivo systems.Stem cell research & therapy · 2019Article
- Bisphenol S and Bisphenol A disrupt morphogenesis of MCF-12A human mammary epithelial cells.Scientific reports · 2019Article
- Identification of matrix physicochemical properties required for renal epithelial cell tubulogenesis by using synthetic hydrogels.Journal of cell science · 2019Article
- Evaluation of PEG-based hydrogel influence on estrogen receptor driven responses in MCF7 breast cancer cells.ACS biomaterials science & engineering · 2019Article
- Membrane associated collagen XIII promotes cancer metastasis and enhances anoikis resistance.Breast cancer research : BCR · 2018Article
- Quantification of the Effect of Toxicants on the Intracellular Kinetic Energy and Cross-Sectional Area of Mammary Epithelial Organoids by OCT Fluctuation Spectroscopy.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Self-organization process in newborn skin organoid formation inspires strategy to restore hair regeneration of adult cells.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- Methylene blue photodynamic therapy induces selective and massive cell death in human breast cancer cells.BMC cancer · 2017Article
- Functional roles of MMP14 and MMP15 in early postnatal mammary gland development.Development (Cambridge, England) · 2016Article
- Nuclear repartitioning of galectin-1 by an extracellular glycan switch regulates mammary morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix.Journal of visualized experiments : JoVE · 2016Article
- An Essential Role for Cdc42 in the Functioning of the Adult Mammary Gland.The Journal of biological chemistry · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue organogenesis is directed by both intercellular interactions and communication with the surrounding microenvironment. When cells are cultured on two-dimensional plastic substrata (2D), important signals controlling programs of cell proliferation, metabolism, differentiation and death responsible for the formation of correct tissue-specific architecture and function are lost. Designing three-dimensional (3D), physiologically relevant culture models, we can recapitulate some crucial aspects of the dynamic and reciprocal signaling necessary for establishing and maintaining tissue specific morphogenic programs. Here we briefly describe the details of robust methods for culturing mouse primary mammary organoids in 3D gels of different extracellular matrices and describe techniques for analyzing the resulting structures. These designer microenvironments are useful for both understanding branching morphogenesis and signaling integrations, but also for analysis of individual susceptibilities and drug testing.
Indexed as
Identifiers
22573197What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.