ArticleEuropean journal of clinical pharmacology2012
Persistence with pharmacological treatment in the specialist mental healthcare of patients with severe mental disorders.
Article in European journal of clinical pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Continuity of Care and Patient Outcomes in Populations With Schizophrenia: A Systematic Review.Psychiatric services (Washington, D.C.) · 2026Pooled it
- Relational continuity may give better clinical outcomes in patients with serious mental illness - a systematic review.BMC psychiatry · 2023Pooled it
- Improvements in Treatment Adherence after Family Psychoeducation in Patients Affected by Psychosis: Preliminary Findings.Journal of personalized medicine · 2023Article
- Influencing factors of medication adherence in schizophrenic patients: a meta-analysis.Schizophrenia (Heidelberg, Germany) · 2023Article
- Does the mental health system provide effective coverage to people with schizophrenic disorder? A self-controlled case series study in Italy.Social psychiatry and psychiatric epidemiology · 2022Article
- Interventions to Improve Medication Adherence in People with Schizophrenia: A Systematic Review.Patient preference and adherence · 2022Review
- Outcomes Among Homeless Patients With Non-Small-Cell Lung Cancer: A County Hospital Experience.JCO oncology practice · 2020Article
- Persistence with treatment for Wilson disease: a retrospective study.BMC neurology · 2019Observational
- Access to and Use of Psychiatric Services by Migrants Resettled in Northern Italy.Journal of immigrant and minority health · 2018Article
- Patterns of persistence with pharmacological treatment among patients with current depressive episode and their impact on long-term outcome: a naturalistic study with 5-year follow-up.Patient preference and adherence · 2018Article
- Prevalence and correlates of QTc prolongation in Italian psychiatric care: cross-sectional multicentre study.Epidemiology and psychiatric sciences · 2016Article
- Time to lack of persistence with pharmacological treatment among patients with current depressive episodes: a natural study with 1-year follow-up.Patient preference and adherence · 2016Article
- Article
- Antipsychotic drug exposure and risk of pulmonary embolism: a population-based, nested case-control study.BMC psychiatry · 2015Article
- Adherence to generic v. brand antidepressant treatment and the key role of health system factors.Epidemiology and psychiatric sciences · 2015Article
- Use of antipsychotic drugs and mood stabilizers in women of childbearing age with schizophrenia and bipolar disorder: epidemiological survey.Epidemiology and psychiatric sciences · 2013Article
- Adherence with general healthcare among internal medicine outpatients with mental health treatment histories.Innovations in clinical neuroscienceArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to measure persistence with pharmacological treatment in the specialist mental healthcare of patients with schizophrenia, bipolar disorder, and unipolar depression in Lombardy, a region of 10 million inhabitants located in the northernmost part of Italy.
methodsThe data concerning psychiatric care used in this study were retrieved from the regional Psychiatric Information System, while information on drug treatment was retrieved from the regional administrative database. Time to lack of persistence with initial pharmacological treatment was the outcome measure.
resultsA total of 11,797 patients, followed in the specialist mental healthcare system, started a new pharmacological treatment for depression, schizophrenia, or bipolar disorder during 2007. Overall, 8,500 patients (72.1%) discontinued treatment during the 12 month follow-up, with a median duration of 101 days. Very similar discontinuation rates were observed in patients with unipolar depression, schizophrenia, and bipolar disorder. In the multivariate analysis, operational definitions of continuity and intensity of care were the most robust determinants of persistence with drug treatment in each of the three cohorts of psychiatric diagnoses.
conclusionsHigh rates of treatment discontinuation were found in a population of patients with severe mental disorders followed in the specialist mental healthcare system of an Italian region, with no differences among patients with unipolar major depression, schizophrenia, and bipolar disorder. These findings corroborate the notion that the problem of treatment discontinuation in psychiatric disorders is a factor related to the capacity of the mental health system to assure and maintain continuity and intensity of care.
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