ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2012
Growth and regression of vasculature in healthy and diabetic mice after hindlimb ischemia.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Single-cell insights into maladaptive endothelial plasticity and therapeutic targets in diabetic vascular complications.Cardiovascular diabetology · 2026Review
- Contrast-Enhanced Ultrasound of Mouse Models of Hindlimb Ischemia Reveals Persistent Perfusion Deficits and Distinctive Muscle Perfusion Patterns.Ultrasound in medicine & biology · 2025Article
- Effects of Interleukin-4 (IL-4)-releasing microparticles and adoptive transfer of macrophages on immunomodulation and angiogenesis.Biomaterials · 2023Article
- Article
- Contrast-Enhanced Ultrasound Reveals Partial Perfusion Recovery After Hindlimb Ischemia as Opposed to Full Recovery by Laser Doppler Perfusion Imaging.Ultrasound in medicine & biology · 2022Article
- Human ADSC xenograft through IL-6 secretion activates M2 macrophages responsible for the repair of damaged muscle tissue.Stem cell research & therapy · 2019Article
- Osteopontin isoforms differentially promote arteriogenesis in response to ischemia via macrophage accumulation and survival.Laboratory investigation; a journal of technical methods and pathology · 2019Article
- Imaging the Proangiogenic Effects of Cardiovascular Drugs in a Diabetic Model of Limb Ischemia.Contrast media & molecular imaging · 2019Article
- Effect of Diallyl Trisulfide on Ischemic Tissue Injury and Revascularization in a Diabetic Mouse Model.Journal of cardiovascular pharmacology · 2018Article
- Drug-Free ROS Sponge Polymeric Microspheres Reduce Tissue Damage from Ischemic and Mechanical Injury.ACS biomaterials science & engineering · 2018Article
- Niacin promotes revascularization and recovery of limb function in diet-induced obese mice with peripheral ischemia.Pharmacology research & perspectives · 2016Article
- A novel platelet lysate hydrogel for endothelial cell and mesenchymal stem cell-directed neovascularization.Acta biomaterialia · 2016Article
- Preclinical evaluation of mesenchymal stem cells overexpressing VEGF to treat critical limb ischemia.Molecular therapy. Methods & clinical development · 2016Article
- Microcomputed tomography: approaches and applications in bioengineering.Stem cell research & therapy · 2014Review
- Quantifying the vascular response to ischemia with speckle variance optical coherence tomography.Biomedical optics express · 2014Article
- Tipping the balance from angiogenesis to fibrosis in CKD.Kidney international supplements · 2014Review
- Polymerase δ-interacting protein 2 promotes postischemic neovascularization of the mouse hindlimb.Arteriosclerosis, thrombosis, and vascular biology · 2014Article
- Mitogen-activated protein kinase phosphatase-1 promotes neovascularization and angiogenic gene expression.Arteriosclerosis, thrombosis, and vascular biology · 2014Article
- Quantitative optical imaging of vascular response in vivo in a model of peripheral arterial disease.American journal of physiology. Heart and circulatory physiology · 2013Article
- Extracellular Matrix Hydrogel Promotes Tissue Remodeling, Arteriogenesis, and Perfusion in a Rat Hindlimb Ischemia Model.JACC. Basic to translational scienceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The formation of vascular networks during embryogenesis and early stages of development encompasses complex and tightly regulated growth of blood vessels, followed by maturation of some vessels, and spatially controlled disconnection and pruning of others. The adult vasculature, while more quiescent, is also capable of adapting to changing physiological conditions by remodeling blood vessels. Numerous studies have focused on understanding key factors that drive vessel growth in the adult in response to ischemic injury. However, little is known about the extent of vessel rarefaction and its potential contribution to the final outcome of vascular recovery. We addressed this topic by characterizing the endogenous phases of vascular repair in a mouse model of hindlimb ischemia. We showed that this process is biphasic. It encompasses an initial rapid phase of vessel growth, followed by a later phase of vessel rarefaction. In healthy mice, this process resulted in partial recovery of perfusion and completely restored the ability of mice to run voluntarily. Given that the ability to revascularize can be compromised by a cardiovascular risk factor such as diabetes, we also examined vascular repair in diabetic mice. We found that paradoxically both the initial growth and subsequent regression of collateral vessels were more pronounced in the setting of diabetes and resulted in impaired recovery of perfusion and impaired functional status. In conclusion, our findings demonstrate that the formation of functional collateral vessels in the hindlimb requires vessel growth and subsequent vessel rarefaction. In the setting of diabetes, the physiological defect was not in the initial formation of vessels but rather in the inability to sustain newly formed vessels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.